Role of primary afferents in arthritis induced spinal microglial reactivity
Increased afferent input resulting from painful injury augments the activity of central
nociceptive circuits via both neuron-neuron and neuron-glia interactions. Microglia, resident …
nociceptive circuits via both neuron-neuron and neuron-glia interactions. Microglia, resident …
Neuron-immune mechanisms contribute to pain in early stages of arthritis
Background Rheumatoid arthritis (RA) patients frequently show weak correlations between
the magnitude of pain and inflammation suggesting that mechanisms other than overt …
the magnitude of pain and inflammation suggesting that mechanisms other than overt …
Pain and immunity
Chronic neuropathic and inflammatory pain is a major public health problem. Nociceptors
undergo sensitization, first in peripheral tissues then in the central nervous sytem, via …
undergo sensitization, first in peripheral tissues then in the central nervous sytem, via …
Macrophages and glial cells: Innate immune drivers of inflammatory arthritic pain perception from peripheral joints to the central nervous system
KF Malange, JM Navia-Pelaez, EV Dias… - Frontiers in Pain …, 2022 - frontiersin.org
Millions of people suffer from arthritis worldwide, consistently struggling with daily activities
due to debilitating pain evoked by this disease. Perhaps the most intensively investigated …
due to debilitating pain evoked by this disease. Perhaps the most intensively investigated …
Microglia-neuron interactions in the models of neuropathic pain
H Tozaki-Saitoh, M Tsuda - Biochemical pharmacology, 2019 - Elsevier
Chronic pain is a debilitating condition that often emerges as a clinical symptom of
inflammatory diseases. It has therefore been widely accepted that the immune system …
inflammatory diseases. It has therefore been widely accepted that the immune system …
Involvement of macrophages and spinal microglia in osteoarthritis pain
T Pan, F Pan, W Gao, S Hu, D Wang - Current Rheumatology Reports, 2021 - Springer
Abstract Purpose of Review Chronic pain in osteoarthritis (OA) is characterized by pain
sensitization, which involves both peripheral and central mechanisms. Studies suggest …
sensitization, which involves both peripheral and central mechanisms. Studies suggest …
Why we should study osteoarthritis pain in experimental models in both sexes
AM Malfait, RE Miller - Osteoarthritis and cartilage, 2020 - oarsijournal.com
Females and males show clear differences in their susceptibility to many diseases, notably
autoimmune diseases and malignancies, but also certain infectious diseases 1. In addition …
autoimmune diseases and malignancies, but also certain infectious diseases 1. In addition …
Role of spinal microglia in rat models of peripheral nerve injury and inflammation
Mounting evidence supports the hypothesis that spinal microglia modulate the development
and maintenance of some chronic pain states. Here we examined the role of spinal …
and maintenance of some chronic pain states. Here we examined the role of spinal …
Calcitonin Gene‐Related Peptide–Expressing Sensory Neurons and Spinal Microglial Reactivity Contribute to Pain States in Collagen‐Induced Arthritis
Objective To evaluate the contribution of sensory neurons in ankle joints and adjacent tissue
to the development of pain in collagen‐induced arthritis (CIA), and to determine the …
to the development of pain in collagen‐induced arthritis (CIA), and to determine the …
Spinal microglia contribute to sustained inflammatory pain via amplifying neuronal activity
Microglia are highly dynamic immune cells of the central nervous system (CNS). Microglial
processes interact with neuronal elements constantly on the order of minutes. The functional …
processes interact with neuronal elements constantly on the order of minutes. The functional …