Sex differences in immune responses that underlie COVID-19 disease outcomes

T Takahashi, MK Ellingson, P Wong, B Israelow… - Nature, 2020 - nature.com
There is increasing evidence that coronavirus disease 2019 (COVID-19) produces more
severe symptoms and higher mortality among men than among women,,,–. However …

A finding of sex similarities rather than differences in COVID-19 outcomes

H Shattuck-Heidorn, AC Danielsen, A Gompers… - Nature, 2021 - nature.com
The sex disparity in COVID-19 mortality varies widely and is of uncertain origin. In their
recent Article, Takahashi et al. 1 assess immune phenotype in a sample of patients with …

Sex differences in immune responses

T Takahashi, A Iwasaki - Science, 2021 - science.org
Evidence increasingly indicates that male sex is a risk factor for more severe disease and
death from COVID-19. Male bias in COVID-19 mortality is observed in nearly all countries …

Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19

R Sparks, WW Lau, C Liu, KL Han, KL Vrindten, G Sun… - Nature, 2023 - nature.com
Acute viral infections can have durable functional impacts on the immune system long after
recovery, but how they affect homeostatic immune states and responses to future …

Immune determinants of COVID-19 disease presentation and severity

P Brodin - Nature medicine, 2021 - nature.com
Abstract COVID-19, caused by SARS-CoV-2 infection, is mild to moderate in the majority of
previously healthy individuals, but can cause life-threatening disease or persistent …

Sex differences in the immune response to acute COVID-19 respiratory tract infection

S Qi, C Ngwa, DA Morales Scheihing… - Biology of sex …, 2021 - Springer
Background Sex differences in COVID-19 are increasingly recognized globally. Although
infection rates are similar between the sexes, men have more severe illness. The …

Considering how biological sex impacts immune responses and COVID-19 outcomes

EP Scully, J Haverfield, RL Ursin… - Nature Reviews …, 2020 - nature.com
A male bias in mortality has emerged in the COVID-19 pandemic, which is consistent with
the pathogenesis of other viral infections. Biological sex differences may manifest …

Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities

LA Bienvenu, J Noonan, X Wang… - Cardiovascular …, 2020 - academic.oup.com
The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic …

The immune response to COVID‐19: Does sex matter?

JQ Ho, MR Sepand, B Bigdelou, T Shekarian… - …, 2022 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has created unprecedented
challenges worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …

[HTML][HTML] Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic interventions

MJ Bunders, M Altfeld - Immunity, 2020 - cell.com
Men present more frequently with severe manifestations of coronavirus disease 2019
(COVID-19) and are at higher risk for death. The underlying mechanisms for these …