How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis
is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three …

Background Immune infiltration of breast tumours is associated with clinical outcome.
However, past work has not accounted for the diversity of functionally distinct cell types that …

Background Increasing evdence supports the suggestion that the immune cell infiltration
(ICI) patterns play a pivotal role in tumor progression in breast cancer (BRCA). Nonetheless …

Background: Not all breast cancer patients benefit from neoadjuvant or adjuvant therapy,
resulting in considerable undertreatment or overtreatment. New insights into the role of …

Background Tumor-infiltrating leukocytes can either limit cancer growth or facilitate its
spread. Diagnostic strategies that comprehensively assess the functional complexity of …

The abundance and functional orientation of tumor-infiltrating lymphocytes in breast cancer
is associated with distant metastasis-free survival, yet how this association is influenced by …

There has been increasing attention on immune-oncology for its impressive clinical benefits
in many different malignancies. However, due to molecular and genetic heterogeneity of …

There is an increasing awareness of the importance of tumor–immune cell interactions to the
evolution and therapy responses of breast cancer (BC). Not surprisingly, numerous studies …

Breast cancer is a very heterogeneous disease, both at a molecular and a histological level.
Five intrinsic subtypes were initially identified—Luminal-A, Luminal-B, HER2+, Triple …

Introduction Tumor microenvironment immunity is associated with breast cancer outcome. A
high lymphocytic infiltration has been associated with response to neoadjuvant …