The development of cost-effective technologies able to comprehensively assess DNA, RNA,
protein, and metabolites in patient tumors has fueled efforts to tailor medical care. Indeed …

The transformation of normal cells into cancer cells and maintenance of the malignant state
and phenotypes are associated with genetic and epigenetic deregulations, altered cellular …

Traditionally, scientific research has focused on studying individual events, such as single
mutations, gene function, or the effect that mutating one protein has on a biological …

Cancer encompasses a complex, heterogeneous and dynamic group of diseases that arise
from perturbations to multiple biological networks within the body. A systems biology-based …

An important challenge facing the field is how better to translate in vitro discoveries to the
clinic. Computational systems biology approaches that use omic data to predict biology …

It is a time of great promise and expectation for the applications of knowledge about
mechanisms of cancer toward more effective and enduring therapies for human disease …

The unprecedented amount of data produced with high-throughput experimentation forces
biologists to employ mathematical representation and computation to glean meaningful …

Background: Personalized medicine is the provision of focused prevention, detection,
prognostic, and therapeutic efforts according to an individual's genetic composition. The …

Current and emerging biomedical science efforts are driven by determining how to improve
clinical outcomes for patients, but the roadmap to achieve this goal has been controversial …

Purpose To describe the emergence of targeted therapies that have led to significant
breakthroughs in cancer therapy and completed or ongoing clinical trials of novel agents for …