Organismal development and cell differentiation critically depend on chromatin state
transitions. However, certain developmentally regulated genes lack histone 3 lysine 9 and …

Background Understanding the function of histone post-translational modifications is the key
to deciphering how genomic activities are regulated. Among the least well-understood …

Histone modifications are critical for the regulation of gene expression, cell type
specification, and differentiation. However, evolutionary patterns of key modifications that …

Histone post-translational modifications (PTMs) and differential incorporation of variant and
canonical histones into chromatin are central modes of epigenetic regulation. Despite …

A defining feature of heterochromatin is methylation of Lys9 of histone H3 (H3K9me), a
binding site for heterochromatin protein 1 (HP1). Although H3K9 methyltransferases and …

Before zygotic genome activation (ZGA), the quiescent genome undergoes reprogramming
to transition into the transcriptionally active state. However, the mechanisms underlying …

Constitutive heterochromatin is essential for transcriptional silencing and genome integrity.
The establishment of constitutive heterochromatin in early embryos and its role in early …

Histone posttranslational modifications mediate establishment of structurally and functionally
distinct chromatin compartments of eukaryotic nuclei. The association of different histone …

Methylation of specific amino acids in histone tails is responsible for packaging DNA into
condensed, repressed chromatin, and into open chromatin that is accessible to the …

Higher eukaryotes must adapt a totipotent genome to specialized cell types with stable but
limited functions. One potential mechanism for lineage restriction is changes in chromatin …