Memory-associated dynamic regulation of the “stable” core of the chromatin particle
IB Zovkic, JD Sweatt - Neuron, 2015 - cell.com
Chromatin is a critical regulator of neural plasticity, but basic principles of chromatin function
in neurons are unclear. In this issue of Neuron, Maze et al.(2015) establish histone H3. 3 …
in neurons are unclear. In this issue of Neuron, Maze et al.(2015) establish histone H3. 3 …
Epigenetics and memory: an expanded role for chromatin dynamics
IB Zovkic - Current Opinion in Neurobiology, 2021 - Elsevier
Highlights•New evidence shows that chromatin regulation is highly dynamic during memory
formation.•Chromatin is modified by incorporating functionally distinct histone variants to …
formation.•Chromatin is modified by incorporating functionally distinct histone variants to …
Critical role of histone turnover in neuronal transcription and plasticity
Turnover and exchange of nucleosomal histones and their variants, a process long believed
to be static in post-replicative cells, remains largely unexplored in brain. Here, we describe a …
to be static in post-replicative cells, remains largely unexplored in brain. Here, we describe a …
The chromatin landscape of neuronal plasticity
Highlights•Histone modifications are highly dynamic in the brain and drive changes in many
behaviors including learning and memory.•Chromatin-associated proteins that interact with …
behaviors including learning and memory.•Chromatin-associated proteins that interact with …
Rapid nucleus-scale reorganization of chromatin in neurons enables transcriptional adaptation for memory consolidation
The interphase nucleus is functionally organized in active and repressed territories defining
the transcriptional status of the cell. However, it remains poorly understood how the nuclear …
the transcriptional status of the cell. However, it remains poorly understood how the nuclear …
Postmitotic accumulation of histone variant H3. 3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity
Histone variants, which can be expressed outside of S-phase and deposited DNA synthesis-
independently, provide long-term histone replacement in postmitotic cells, including …
independently, provide long-term histone replacement in postmitotic cells, including …
Histone regulation in the CNS: basic principles of epigenetic plasticity
I Maze, KM Noh, CD Allis - Neuropsychopharmacology, 2013 - nature.com
Postmitotic neurons are subject to a vast array of environmental influences that require the
nuclear integration of intracellular signaling events to promote a wide variety of neuroplastic …
nuclear integration of intracellular signaling events to promote a wide variety of neuroplastic …
In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory
Highlights•Epigenetic regulation represents a key mechanism of learning, memory and
cognition.•Chromatin topology is emerging as a major regulator of neuronal gene …
cognition.•Chromatin topology is emerging as a major regulator of neuronal gene …
An emerging perspective on 'histone code'mediated regulation of neural plasticity and disease
LA Farrelly, I Maze - Current opinion in neurobiology, 2019 - Elsevier
Highlights•Histone regulation in brain is a central determinant of neural development and
plasticity.•Many neurological diseases are linked to aberrant histone regulation in the …
plasticity.•Many neurological diseases are linked to aberrant histone regulation in the …
Chromatin changes associated with neuronal maintenance and their pharmacological application
Background: The transcriptional control of neuronal specification and early development has
been intensively studied over the past few decades. However, relatively little is known about …
been intensively studied over the past few decades. However, relatively little is known about …