Charting the landscape of genetic overlap between mental disorders and related traits beyond genetic correlation
Objective: Mental disorders are heritable and polygenic, and genome-wide genetic
correlations (rg) have indicated widespread shared genetic risk across multiple disorders …
correlations (rg) have indicated widespread shared genetic risk across multiple disorders …
Assessing the evidence for shared genetic risks across psychiatric disorders and traits
Genetic influences play a significant role in risk for psychiatric disorders, prompting
numerous endeavors to further understand their underlying genetic architecture. In this …
numerous endeavors to further understand their underlying genetic architecture. In this …
Phenotypically independent profiles relevant to mental health are genetically correlated
Genome-wide association studies (GWAS) and family-based studies have revealed partly
overlapping genetic architectures between various psychiatric disorders. Given clinical …
overlapping genetic architectures between various psychiatric disorders. Given clinical …
The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges
Genome-wide association studies have transformed psychiatric genetics and provided novel
insights into the genetic etiology of psychiatric disorders. Two major discoveries have …
insights into the genetic etiology of psychiatric disorders. Two major discoveries have …
Embracing polygenicity: a review of methods and tools for psychiatric genetics research
RM Maier, PM Visscher, MR Robinson… - Psychological …, 2018 - cambridge.org
The availability of genome-wide genetic data on hundreds of thousands of people has led to
an equally rapid growth in methodologies available to analyse these data. While the …
an equally rapid growth in methodologies available to analyse these data. While the …
Shared genetic architecture across psychiatric disorders
AD Grotzinger - Psychological medicine, 2021 - cambridge.org
Psychiatric disorders overlap substantially at the genetic level, with family-based methods
long pointing toward transdiagnostic risk pathways. Psychiatric genomics has progressed …
long pointing toward transdiagnostic risk pathways. Psychiatric genomics has progressed …
Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis
We interrogate the joint genetic architecture of 11 major psychiatric disorders at
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
Accumulating evidence from genome wide association studies (GWAS) suggests an
abundance of shared genetic influences among complex human traits and disorders, such …
abundance of shared genetic influences among complex human traits and disorders, such …
Examining the shared etiology of psychopathology with genome-wide association studies
TT Mallard, AD Grotzinger… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …
Not just one p: Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities
A single dimension of general psychopathology, p, has been hypothesized to represent a
general liability that spans multiple types of psychiatric disorders and non-clinical variation …
general liability that spans multiple types of psychiatric disorders and non-clinical variation …