Molnupiravir, an oral antiviral treatment for COVID-19

W Fischer, JJ Eron Jr, W Holman, MS Cohen, L Fang… - MedRxiv, 2021 - medrxiv.org
Background Easily distributed oral antivirals are urgently needed to treat coronavirus
disease-2019 (COVID-19), prevent progression to severe illness, and block transmission of …

An updated practical guideline on use of molnupiravir and comparison with agents having emergency use authorization for treatment of COVID-19

AK Singh, A Singh, R Singh, A Misra - Diabetes & Metabolic Syndrome …, 2022 - Elsevier
Background and aims Molnupiravir is a newer oral antiviral drug that has recently received
emergency use authorization (EUA) in USA, UK and India. We aim to conduct an update on …

[HTML][HTML] Molnupiravir—a step toward orally bioavailable therapies for Covid-19

R Whitley - New England Journal of Medicine, 2022 - Mass Medical Soc
The Covid-19 pandemic has resulted in substantial global morbidity and mortality as well as
disruption of the economies of virtually every country. 1 Some of this tragedy could have …

Randomized controlled trial of molnupiravir SARS-CoV-2 viral and antibody response in at-risk adult outpatients

JF Standing, L Buggiotti, JA Guerra-Assuncao… - Nature …, 2024 - nature.com
Viral clearance, antibody response and the mutagenic effect of molnupiravir has not been
elucidated in at-risk populations. Non-hospitalised participants within 5 days of SARS-CoV-2 …

Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled …

SH Khoo, R FitzGerald, G Saunders… - The Lancet Infectious …, 2023 - thelancet.com
Background The antiviral drug molnupiravir was licensed for treating at-risk patients with
COVID-19 on the basis of data from unvaccinated adults. We aimed to evaluate the safety …

Molnupiravir: from hope to epic fail?

D Focosi - Viruses, 2022 - mdpi.com
Molnupiravir has been the first oral antiviral authorized for COVID-19 outpatients, reporting
extraordinary sales and preserved in vitro efficacy against Omicron sublineages so far …

Real-world experience with molnupiravir during the period of SARS-CoV-2 Omicron variant dominance

R Flisiak, D Zarębska-Michaluk, M Rogalska… - Pharmacological …, 2022 - Springer
Background The real-world effectiveness of molnupiravir (MOL) during the dominance of
Omicron SARS-CoV-2 lineage is urgently needed since the available data relate to the …

Real-world effectiveness of molnupiravir and nirmatrelvir/ritonavir as treatments for COVID-19 in patients at high risk

D Paraskevis, M Gkova, K Mellou… - The Journal of …, 2023 - academic.oup.com
Background Using a retrospective cohort study design, we aimed to evaluate the
effectiveness of molnupiravir and nirmatrelvir/ritonavir in patients with SARS-CoV-2 who …

[HTML][HTML] The emergence of powerful oral anti-COVID-19 drugs in the post-vaccine era

H Fan, F Lou, J Fan, M Li, Y Tong - The Lancet Microbe, 2022 - thelancet.com
The quest for effective drugs to treat COVID-19 has been a priority since the outbreak of the
disease. The clinical application of remdesivir has been greatly restricted by the need for …

New perspectives on antimicrobial agents: molnupiravir and nirmatrelvir/ritonavir for treatment of COVID-19

RL Atmar, N Finch - Antimicrobial agents and chemotherapy, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged to cause
pandemic respiratory disease in the past 2 years, leading to significant worldwide morbidity …