Tumor metastasis is the main cause of cancer‐related death. Understanding the molecular
mechanisms underlying tumor metastasis is crucial to control this fatal disease. Several …

Angiogenesis is an essential aspect of tumour growth and metastasis. Solid tumours cannot
grow beyond 2-3 mm in diameter without inducing the formation of new blood vessels to …

Tumor blood vessels play important roles in tumor progression and metastasis. Thus,
targeting tumor blood vessels is an important strategy for cancer therapy. Tumor endothelial …

Communication between tumor cells and stromal cells is crucial to tumor development and
progression. Fibroblasts and macrophages are the most common stromal cells in the tumor …

The vascular endothelium is a dynamic cellular “organ” that controls passage of nutrients
into tissues, maintains the flow of blood, and regulates the trafficking of leukocytes. In …

Tumor blood vessels supply nutrients and oxygen to tumor cells for their growth and provide
routes for them to enter circulation. Thus, angiogenesis, the formation of new blood vessels …

Robust neovascularization and lymphangiogenesis have been found in a variety of
aggressive and metastatic tumors. Endothelial sprouting angiogenesis is generally …

Tumor blood vessels provide nutrition and oxygen to the tumor, resulting in tumor
progression. They also act as gatekeepers, inducing tumor metastasis. Thus, targeting tumor …

Metastasis refers to the spread of cancer cells from a primary tumor to distant organs mostly
via the bloodstream. During the metastatic process, cancer cells invade blood vessels to …

Tumour blood vessels are gateways for distant metastasis. Recent studies have revealed
that tumour endothelial cells (TECs) demonstrate distinct phenotypes from their normal …