The prevalence of colorectal adenoma in 23 affected patients with hereditary non-polyposis
colorectal cancer (HNPCC) was compared with that in an age matched forensic autopsy …

Pathological characteristics of colorectal cancers and adenomas developing in 140
members of 34 Hereditary Non-Polyposis Colorectal Cancer (HNPCC) families are …

An understanding of the early morphogenesis of hereditary non‐polyposis colorectal cancer
is relevant to screening strategies. If most of these cancers were to evolve through the …

The results of screening individuals referred to the Family Cancer Clinic at St Mark's Hospital
from 1986 are presented. Colonoscopy was performed in 644 asymptomatic individuals …

A surveillance programme comprising either colonoscopy or sigmoidoscopy plus barium
enema every 2–3 years was instituted in 50 hereditary nonpolyposis colorectal cancer …

Abstract purpose: Identification of the hereditary non-polyposis colorectal carcinoma
syndrome (HNPCC) is a basis for secondary prevention. The objectives of this study are to …

Hereditary nonpolyposis colorectal cancer (HNPCC) results from an inherited defect in one
of the genes responsible for repair of errors that occur during DNA replication. Affected …

The main characteristic of the syndrome is an autosomal dominant mode of transmission of
adenocarcinomas, which can be clearly demonstrated in classical HNPCC families (Fig. 1) …

The frequency of hereditary nonpolyposis colorectal cancer was evaluated in a group of
colorectal cancer patients under age 50 diagnosed in southern Alberta between 1973 and …

Hereditary non‐polyposis colorectal cancer (HNPCC or Lynch syndrome) is characterized
by the early onset of colorectal neoplasms, frequently localized in the right colon, increased …