ABSTRACT Coenzyme Q10 (CoQ10) is a component of the antioxidant machinery that
protects cell membranes from oxidative damage and decreases apoptosis in leukemic cells …

Coenzyme Q (CoQ) is the key factor for the activity of the eukaryotic plasma membrane
electron transport chain. Consequently, CoQ is essential in the cellular response against …

Serum withdrawal is a model to study the mechanisms involved in the induction of apoptosis
caused by mild oxidative stress. Apoptosis induced by growth factors removal was …

The plasma membrane of animal cells contains an electron transport system based on
coenzyme Q (CoQ) reductases. Cytochrome b 5 reductase is NADH-specific and reduces …

The permeability transition pore (PTP) is a mitochondrial channel whose opening causes
the mitochondrial membrane potential (ΔΨ) collapse that leads to apoptosis. Some …

Publisher Summary This chapter reviews the methods that are most useful to study the role
of CoQ and its reductases in the regulation of liver plasma membrane SMase (nSMase) …

The mitochondrial component coenzyme Q10 (CoQ10 b) Has been used for many years as
a Dietary supplement intended to promote good health by trapping free radicals, thus …

Generation of free radicals is often associated with the induction and progression of
apoptosis. Therefore, antioxidants can prove anti-apoptotic, and can help to elucidate …

Oxidative stress leads to mitochondrial dysfunction, which triggers the opening of the
permeability transition pores (PTP) and the release of pro-apoptotic factors causing …

Recent studies indicate that caspase-2 is involved in the early stages of apoptosis,
particularly before the occurrence of mitochondrial damage. Here we report the important …