In many cellular signaling pathways, key components form clusters at the cell membrane.
Although much work has focused on the mechanisms behind such cluster formation, the …

New experimental techniques, especially in the context of observing molecular dynamics,
reveal the plasma membrane to be heterogeneous and" scale rich," from nanometers to …

Spatial heterogeneity is a hallmark of living systems, even at the molecular scale in
individual cells. A key example is the partitioning of membrane-bound proteins via lipid …

Initiation and propagation of cell signaling depend on productive interactions among
signaling proteins at the plasma membrane. These diffusion-limited interactions can be …

Receptor clustering is a well-established feature of transmembrane signalling. In some
cellular systems, clusters form dynamically in response to activation by an extracellular …

Recent observations in the field of signal transduction suggest that where a protein is
located within a cell can be as important as its activity measured in solution for activation of …

Background Cellular response to changes in the concentration of different chemical species
in the extracellular medium is induced by ligand binding to dedicated transmembrane …

In living cells and biomimetic systems alike, multivalent ligands in solution can induce
clustering of membrane receptors. The link between the receptor clustering and the ligand …

Systems biology modeling of signal transduction pathways traditionally employs ordinary
differential equations, deterministic models based on the assumptions of spatial …

Protein–protein dimerization is ubiquitous in biology, but its role in self-organization remains
unexplored. Here we use Monte Carlo simulations to demonstrate that under diffusion …