Drug–drug interactions are a major concern not only during clinical practice, but also in drug
development. Due to limitations of in vitro–in vivo predictions of transporter-mediated drug …

Comprehensive characterization of transporter mediated drug‐drug interactions (DDIs) is
important to formulate clinical management strategies and ensure the safe and effective use …

Drug transporters expressed in liver and kidney play a critical role in the elimination of a
wide range of drugs and xenobiotics and inhibition of these transporters may therefore …

Introduction: It is becoming increasingly evident that transporters play an important role in
the absorption, distribution and elimination of many drugs. Different approaches have been …

Establishing the methods for the effective screening of compounds with optimal
pharmacokinetic properties is of great importance to many scientists working in new drug …

Transporters govern the access of molecules to cells or their exit from cells, thereby
controlling the overall distribution of drugs to their intracellular site of action. Clinically …

We aim to establish an in vivo preclinical model to enable simultaneous assessment of
inhibition potential of an investigational drug on clinically relevant drug transporters, organic …

This white paper addresses current approaches and knowledge gaps concerning methods
to assess the role of transport proteins in drug/metabolite disposition in humans. The …

Introduction: Membrane transporters have been recognized to play a key role in determining
the absorption, distribution and elimination processes of drugs. The organic anion …

Transport proteins play an important role in the adsorption, distribution and elimination of a
wide variety of drugs. Therefore, it is not surprising that transporter-based drug interactions …