Combination of targeted delivery and controlled release is a powerful technique for cancer
treatment. In this paper, we describe the design, synthesis, structure validation and …

N-(2-Hydroxypropyl) methacrylamide (HPMA) copolymer–docetaxel–RGDfK conjugate was
synthesized, characterized, and evaluated in vitro and in vivo in comparison with untargeted …

Prostate cancer (PCa) is the most prevalent cancer among men in the United States and
remains the second-leading cause of cancer mortality in men. Paclitaxel (PTX) is the first line …

This work describes the enhancement of a novel antitumor therapeutic platform that
combines advantages from small-molecule drug conjugates (SMDCs) and antibody drug …

Prostate cancer is one of the most commonly diagnosed men's cancers and remains one of
the leading causes of cancer death. The development of approaches to the treatment of this …

Prostate cancer (PC) is the second most commonly occurring cancer in men. Conventional
chemotherapy has wide variety of disadvantages such as high systemic toxicity and low …

Biodistribution, pharmacokinetics, and efficacy of prostate‐cancer‐targeted HPMA
copolymer/DTX conjugates are evaluated in nude mice bearing prostate cancer C4‐2 …

In this paper we describe the synthesis, physicochemical characteristics and data on the
biological activity of polymer prodrugs based on the anticancer drugs paclitaxel (PTX) and …

The tumor-specific targeting of cancerostatics using polymer drug carriers represents a
potential strategy to achieve an effective treatment with reduced side toxicity. Synthetic water …

An amphiphilic polymer-drug conjugate was prepared by attachment of low molecular
weight methoxy poly (ethylene glycol)(PEG)(ie, 2 kDa) to docetaxel (DTX) through an ester …