Understanding complex tissues requires single-cell deconstruction of gene regulation with
precision and scale. Here, we assess the performance of a massively parallel droplet-based …

T cells create vast amounts of diversity in the genes that encode their T cell receptors
(TCRs), which enables individual clones to recognize specific peptide–major …

Recent technical advancements have facilitated the mapping of epigenomes at single-cell
resolution; however, the throughput and quality of these methods have limited their …

Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …

The assay for transposase-accessible chromatin using sequencing (ATAC-seq) is widely
used to identify regulatory regions throughout the genome. However, very few studies have …

Tissue function depends on cellular organization. While the properties of individual cells are
increasingly being deciphered using powerful single-cell sequencing technologies …

T cell exhaustion limits antitumor immunity, but the molecular determinants of this process
remain poorly understood. Using a chronic stimulation assay, we performed genome-wide …

Cancer is a heterogeneous and complex disease. Tumors are formed by cancer cells and a
myriad of non-cancerous cell types that together with the extracellular matrix form the tumor …

Background Recent innovations in single-cell Assay for Transposase Accessible Chromatin
using sequencing (scATAC-seq) enable profiling of the epigenetic landscape of thousands …

Several limitations of current epigenomic technology preclude their use in many
experimental and clinical settings. Here we describe Assay for Transposase Accessible …