Aims: The in vivo formation of salsolinol (1-methyl-6, 7-dihydroxy-1, 2, 3, 4-
tetrahydroisoquionoline), an endogeneous condensation product of dopamine (DA) with …

Background: Salsolinol, a neuropharmacologically active compound, is formed by the
condensation of acetaldehyde (AcH) with dopamine (DA) in the brain. The aim of our study …

Regional contents of salsolinol and catecholamines in the brain of normal and ethanol-
treated rats were studied. Male Sprague-Dawley rats were given ethanol solution as sole …

Endogenous levels of salsolinol and dopamine were measured by a gas
chromatography/mass spectrometry (GC/MS)—selected ion monitoring technique using …

The effects of acetaldehyde (ACD) on dopamine (DA) and DA-derived salsolinol (SAL)
levels were investigated in the striatum of freely moving rats. Dialysate levels of DA and SAL …

Using a microdialysis-HPLC technique in conscious rats, we examined the action of (R)-1-
methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline,(R)-salsolinol (R-Sal), a possible …

To assess the dose-dependent effect of cyanamide (CY, a potent aldehyde dehydrogenase
inhibitor) on salsolinol release in the striatum, rats were treated with CY (25, 50 and 100 …

Salsolinol (SAL), a condensation product of dopamine and acetaldehyde that appears in the
rat and human brain after ethanol ingestion, has been largely implicated in the aetiology of …

Endogenous levels of salsolinol and its methylated metabolite were measured by combined
gas chromatography and mass spectrometry in rats chronically exposed to ethanol for 150 …

The 6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (TIQ), salsolinol, is a substantial
constituent along with its mono-O-methylated metabolite (s) in urine obtained from alcoholic …