Objective In arthritis, macrophages invade the affected joint. Experimental arthritis models
have shown that macrophages also invade the dorsal root ganglia (DRGs) of the inflamed …

After peripheral nerve damage macrophages infiltrate the dorsal root ganglia (DRG) in
which cell bodies of lesioned neurons are located. However, infiltration of macrophages into …

Abstract Introduction Interleukin-6 (IL-6) is an important mediator of inflammation. In addition
to cells involved in inflammation, sensory nociceptive neurons express the IL-6 signal …

Introduction Numerous observations indicate that rheumatoid arthritis (RA) has a bone
marrow component. In parallel, local synovial changes depend on neuronal components of …

Objective To evaluate the contribution of sensory neurons in ankle joints and adjacent tissue
to the development of pain in collagen‐induced arthritis (CIA), and to determine the …

Females and males show clear differences in their susceptibility to many diseases, notably
autoimmune diseases and malignancies, but also certain infectious diseases 1. In addition …

Background Central nervous system (CNS)-mediated symptoms, such as fatigue,
depression, and hyperalgesia, are common complications among patients with rheumatoid …

Pain is the major debilitating symptom of osteoarthritis (OA), which is difficult to treat. In OA
patients joint tissue damage only poorly associates with pain, indicating other mechanisms …

Bidirectional interactions between the immune system and the nervous system are
increasingly appreciated as playing a pathogenic role in chronic pain. Unraveling the …

Objective Pain is a prominent feature of osteoarthritis (OA). To further understand the
primary mechanisms of nociception in OA, we studied the expression of the phenotype …