The trk family of oncogenes and neurotrophin receptors.
F Lamballe, R Klein, M Barbacid - Princess Takamatsu symposia, 1991 - europepmc.org
To date more than twenty five different oncogenes have been identified in human
neoplasias. One of these oncogenes is trk, a transforming gene originally isolated from a …
neoplasias. One of these oncogenes is trk, a transforming gene originally isolated from a …
The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
R Klein, V Nanduri, S Jing, F Lamballe, P Tapley… - Cell, 1991 - cell.com
Summary trkB is a tyrosine protein kinase gene highly related to trk, a proto-oncogene that
encodes a receptor for nerve growth factor (NGF) and neurotrophin-3(NT-3). t&B expression …
encodes a receptor for nerve growth factor (NGF) and neurotrophin-3(NT-3). t&B expression …
Structural and functional properties of the TRK family of neurotrophin receptors.
M Barbacid - Annals of the new York Academy of Sciences, 1995 - europepmc.org
The Trk family of tyrosine-protein kinases, TrkA, TrkB, and TrkC, are the signaling receptors
that mediate the biological properties of the NGF family of neurotrophins. This family of …
that mediate the biological properties of the NGF family of neurotrophins. This family of …
trkC encodes multiple neurotrophin‐3 receptors with distinct biological properties and substrate specificities.
F Lamballe, P Tapley, M Barbacid - The EMBO Journal, 1993 - embopress.org
The trkC gene product gp145trkC is a high affinity signaling receptor for neurotrophin‐3 (NT‐
3), a member of the NGF family of neurotrophic factors. We now report that trkC encodes at …
3), a member of the NGF family of neurotrophic factors. We now report that trkC encodes at …
trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3
F Lamballe, R Klein, M Barbacid - Cell, 1991 - cell.com
We report the isolation and molecular characterization of t&C, a new member of the trk family
of tyrosine protein kinase genes. t&C is preferentially expressed in the brain. In situ …
of tyrosine protein kinase genes. t&C is preferentially expressed in the brain. In situ …
The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3
C Cordon-Cardo, P Tapley, S Jing, V Nanduri… - Cell, 1991 - cell.com
The product of the trk proto-oncogene encodes a receptor for nerve growth factor (NGF).
Here we show that NGF is a powerful mitogen that can induce resting NIH 3T3 cells to enter …
Here we show that NGF is a powerful mitogen that can induce resting NIH 3T3 cells to enter …
The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines
DM Loeb, J Maragos, D Martin-Zanca, MV Chao… - Cell, 1991 - cell.com
The trk tyrosine kinase proto-oncogene product gp140p'“'o” k binds nerve growth factor
(NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine …
(NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine …
Transfection of TRK-A into human neuroblastoma cells restores their ability to differentiate in response to nerve growth factor.
E Lavenius, C Gestblom, I Johansson… - Cell growth & …, 1995 - europepmc.org
Human neuroblastoma cell lines frequently express the TRK-A proto-oncogene and bind
nerve growth factor (NGF) but do not differentiate when exposed to NGF. Transient …
nerve growth factor (NGF) but do not differentiate when exposed to NGF. Transient …
Identification and biochemical characterization of p70TRK, product of the human TRK oncogene.
G Mitra, D Martin-Zanca… - Proceedings of the …, 1987 - National Acad Sciences
TRK is a human transforming gene generated in a colon carcinoma by a somatic
rearrangement that fused a nonmuscle tropomyosin gene to sequences that shared …
rearrangement that fused a nonmuscle tropomyosin gene to sequences that shared …
Expression of TRK-T1 oncogene induces differentiation of PC12 cells
A Greco, R Orlandi, C Mariani, C Miranda… - Cell growth and …, 1993 - AACR
The TRK-T1 oncogene, isolated from a human thyroid carcinoma, represents a rearranged
form of the high affinity nerve growth factor (NGF) receptor encoded by the NTRK1 gene; it is …
form of the high affinity nerve growth factor (NGF) receptor encoded by the NTRK1 gene; it is …