Where does the fluorine come from? A review on the challenges associated with the synthesis of organofluorine compounds

S Caron - Organic Process Research & Development, 2020 - ACS Publications
Fluorinated organic molecules are increasingly being prepared for a variety of applications,
including pharmaceutical products. However, the supply chain to access the necessary raw …

Synthetic approaches to monofluoroalkenes

G Landelle, M Bergeron, MO Turcotte-Savard… - Chemical Society …, 2011 - pubs.rsc.org
Monofluoroalkenes are an important fluorinated class of compounds with applications in
medicinal chemistry, material sciences and organic chemistry. An overview of methods …

A fruitful decade of organofluorine chemistry: new reagents and reactions

FL Qing, XY Liu, JA Ma, Q Shen, Q Song… - CCS …, 2022 - chinesechemsoc.org
The development of synthetic methods for the introduction of the fluorine atom and
fluoroalklyl groups into organic molecules has gained increased attention. Synthetic organic …

Contemporary synthetic strategies in organofluorine chemistry

R Britton, V Gouverneur, JH Lin, M Meanwell… - Nature Reviews …, 2021 - nature.com
Fluorinated molecules have a wide range of applications and are used as medicines,
agrochemicals and refrigerants and in smartphone liquid crystal displays, photovoltaic solar …

Fluorination methods for drug discovery and development

P Richardson - Expert Opinion on Drug Discovery, 2016 - Taylor & Francis
Introduction: The pivotal role that the element fluorine plays in modulating the properties of
bioactive molecules is reflected by the growth of its presence in approved drugs. In 1970 …

Modern carbon–fluorine bond forming reactions for aryl fluoride synthesis

MG Campbell, T Ritter - Chemical Reviews, 2015 - ACS Publications
In recent years, there has been a dramatic increase in available methods for the installation
of fluorine and fluorine-containing functional groups in organic molecules, 1− 4 and the …

Introduction of fluorine and fluorine‐containing functional groups

T Liang, CN Neumann, T Ritter - … Chemie International Edition, 2013 - Wiley Online Library
Over the past decade, the most significant, conceptual advances in the field of fluorination
were enabled most prominently by organo‐and transition‐metal catalysis. The most …

Late-stage fluorination: fancy novelty or useful tool?

CN Neumann, T Ritter - Angewandte Chemie (International ed. in …, 2015 - europepmc.org
Charming fluorine: This Essay examines the recent surge in late-stage fluorination reactions
and outlines challenges that need to be overcome to increase the impact of modern …

Modern synthetic methods for fluorine‐substituted target molecules

M Shimizu, T Hiyama - Angewandte Chemie International …, 2005 - Wiley Online Library
Fluorine has come to be recognized as a key element in materials science: in heat‐transfer
agents, liquid crystals, dyes, surfactants, plastics, elastomers, membranes, and other …

Organofluorine chemistry: applications, sources and sustainability

A Harsanyi, G Sandford - Green chemistry, 2015 - pubs.rsc.org
Fluorine is an essential element for life in the developed world that impacts hugely on the
general public because many pharmaceuticals, agrochemicals, anaesthetics, materials and …