Background Poor placental function is a common cause of intrauterine growth restriction,
which in turn is associated with increased risks of adverse health outcomes. Our prior work …

Placental cell growth depends on an adaptable combination of an endogenous
developmental program and the exogenous influence of maternal growth factors, both of …

MicroRNAs are non-coding RNAs that regulate gene expression post-transcriptionally. In the
placenta, the master regulator of foetal growth and development, microRNAs shape the …

Objective The epigenetic mechanisms underlying fetal metabolic programming are poorly
understood. We studied whether obesity is associated with alterations in placental miRNA …

Birth weight (BW) represents an important clinical and toxicological measure, indicative of
the overall health of the newborn as well as potential risk for later-in-life outcomes. BW can …

Introduction MicroRNAs regulate post-transcriptional gene expression. Their expression has
been linked to many pregnancy complications, including preterm birth. Placental microRNA …

GWAS identified variants associated with birth weight (BW), childhood obesity (CO) and
childhood BMI (CBMI), and placenta is a critical organ for fetal development and postnatal …

In the United States, cardiovascular disease is the leading cause of death and the rate of
maternal mortality remains among the highest of any industrialized nation. Maternal …

Objectives Previous studies have suggested that the expression and function of placenta-
specific microRNAs (miRNAs) are associated with placenta trophoblastic proliferation and …

Fetal growth is dependent on appropriate growth and function of the placenta. This is
modulated by a variety of factors, including maternal growth factors that exert their actions by …