The intestinal epithelium is faced with the complex task of providing a barrier while also
allowing nutrient and water absorption. The frequency with which these processes are …

Dynamic regulation of paracellular permeability is essential for physiological epithelial
function, while dysregulated permeability is common in disease. The recent elucidation of …

Disruption of the intestinal epithelial barrier occurs in many intestinal diseases, but neither
the mechanisms nor the contribution of barrier dysfunction to disease pathogenesis have …

The major and rate-limiting barrier to transepithelial permeation in the intestine is the
intercellular tight junction. Tight junction structure is often cell type specific and general but …

The gastrointestinal tract is a specialized organ in which dynamic interactions between host
cells and the complex environment occur in addition to food digestion. Together with the …

Epithelia form barriers that are essential to life. This is particularly true in the intestine, where
the epithelial barrier supports nutrient and water transport while preventing microbial …

The intestinal epithelial monolayer constitutes a physical and functional barrier between the
organism and the external environment. It regulates nutrients absorption, water and ion …

The intestinal epithelium forms a key protective barrier that separates internal organs from
the harmful environment of the gut lumen. Increased permeability of the gut barrier is a …

The intestinal epithelium is a single-cell layer that constitutes the largest and most important
barrier against the external environment. It acts as a selectively permeable barrier …

A critical function of the intestinal mucosa is to form a barrier that separates luminal contents
from the interstitium. This intestinal barrier is compromised in a number of intestinal …