A core function of epithelia is to form barriers that separate tissue compartments within
complex organisms. These barriers also separate the internal milieu from the external …

The colonic mucosa provides a vital defensive barrier separating the body from the microbial
populations residing in the intestinal lumen. Indeed, growing evidence shows that loss of …

The intestinal epithelial apical junctional complex, which includes tight and adherens
junctions, contributes to the intestinal barrier function via their role in regulating paracellular …

The mucosal epithelia of the digestive tract acts as a selective barrier, permeable to ions,
small molecules and macromolecules. These epithelial cells aid the digestion of food and …

The tight junction forms a barrier against unlimited paracellular passage but some of the
tight junction proteins just do the opposite, they form extracellular channels zigzagging …

Studies of the impact of enteric pathogens and their virulence factors on the proteins
comprising the tight junction and zonula adherens offer a novel approach to dissection of …

The goal of this review is to describe barrier function of the intestine, the structure of the tight
junction, methods to evaluate intestinal permeability, and most importantly the relevance of …

A key feature of inflammatory bowel disease (IBD) is disruption of the intestinal epithelial
barrier by unknown mechanisms. Integrity of the epithelial barrier is determined by an apical …

The etiology of human inflammatory bowel diseases (IBDs) is believed to involve
inappropriate host responses to the complex commensal microbial flora in the gut, although …

The intestinal epithelial monolayer forms a transcellular and paracellular barrier that
separates luminal contents from the interstitium. The paracellular barrier consists of a highly …