The holy grail of tumor modeling is to formulate theoretical and computational tools that can
be utilized in the clinic to predict neoplastic progression and propose individualized optimal …

Cancer is a complex, multiscale process involving interactions at intracellular, intercellular
and tissue scales that are in turn susceptible to microenvironmental changes. Each …

Simple Summary Omics technologies and targeted drugs are revolutionizing the clinical
oncology landscape, portending the promise of precision oncology. However, our abilities to …

Network biology has garnered tremendous attention in understanding complex systems of
cancer, because the mechanisms underlying cancer involve the perturbations in the specific …

Cancer immunotherapy, an approach of targeting immune cells to attack tumor cells, has
been suggested to be a promising way for cancer treatment recently. However, the …

Motivation: Multicellular systems, such as tissues, are composed of different cell types that
form a heterogeneous community. Behavior of these systems is determined by complex …

What do complex networks, such as those found in cancer cells, airplane flight patterns and
the Internet have in common? A remarkable robustness with a surprising vulnerability …

Despite massive investments in drug research and development, the significant decline in
the number of new drugs approved or translated to clinical use raises the question, whether …

Targeted therapies aim to prevent cancer progression by inactivating tumor-specific
signaling pathways. However, identifying a suitable drug target in the signaling network …

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influence more than one protein, either: as a consequence of structural similarities between …