High levels of circulating IL-8 and soluble IL-2R are associated with prolonged illness in patients with severe COVID-19

A Ma, L Zhang, X Ye, J Chen, J Yu, L Zhuang… - Frontiers in …, 2021 - frontiersin.org
Objectives The coordinated immune response of the host is the key of the successful combat
of the body against SARS-CoV-2 infection and is decisive for the development and …

Cytokine profiles associated with acute COVID-19 and long COVID-19 syndrome

MAF Queiroz, PFM Neves, SS Lima… - Frontiers in cellular …, 2022 - frontiersin.org
The duration and severity of COVID-19 are related to age, comorbidities, and cytokine
synthesis. This study evaluated the impact of these factors on patients with clinical …

Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19

H Hou, B Zhang, H Huang, Y Luo, S Wu… - Clinical & …, 2020 - academic.oup.com
Effective laboratory markers for the estimation of disease severity and predicting the clinical
progression of coronavirus disease-2019 (COVID-19) is urgently needed. Laboratory tests …

Cytokines and their relationship with the severity and prognosis of coronavirus disease 2019 (COVID-19): a retrospective cohort study

QQ Liu, A Cheng, Y Wang, H Li, L Hu, X Zhao… - BMJ open, 2020 - bmjopen.bmj.com
Objective To delineate the characteristics and clinical significance of plasma inflammatory
cytokines altered in COVID-19. Design Retrospective, single-centre cohort study. Setting …

Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors

H Han, Q Ma, C Li, R Liu, L Zhao, W Wang… - Emerging microbes & …, 2020 - Taylor & Francis
Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly
spread across many other countries. While the majority of patients were considered mild …

Associations between Serum Interleukins (IL‐1β, IL‐2, IL‐4, IL‐6, IL‐8, and IL‐10) and Disease Severity of COVID‐19: A Systematic Review and Meta‐Analysis

Y Chang, M Bai, Q You - BioMed Research International, 2022 - Wiley Online Library
Background. To investigate the association between interleukins (IL‐1β, IL‐2, IL‐4, IL‐6, IL‐
8, and IL‐10) and the disease severity of coronavirus disease 2019 (COVID‐19). Materials …

The anti-inflammatory cytokine response characterized by elevated interleukin-10 is a stronger predictor of severe disease and poor outcomes than the pro …

BM Henry, SW Benoit, J Vikse, BA Berger… - Clinical Chemistry and …, 2021 - degruyter.com
Objectives Severe coronavirus disease 2019 (COVID-19) is associated with a dysregulated
immune state. While research has focused on the hyperinflammation, little research has …

IFN-γ is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection

AC Gadotti, M de Castro Deus, JP Telles, R Wind… - Virus research, 2020 - Elsevier
Background Innate and adaptive immune responses have been evaluated in infected
patients with COVID-19. The severity of the disease has been supposed to be associated …

Cytokine signature associated with disease severity in COVID-19

J Guo, S Wang, H Xia, D Shi, Y Chen, S Zheng… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) broke out and then became a global epidemic at the
end of 2019. With the increasing number of deaths, early identification of disease severity …

The potential role of IL-6 in monitoring severe case of coronavirus disease 2019

T Liu, J Zhang, Y Yang, H Ma, Z Li, J Zhang, J Cheng… - MedRxiv, 2020 - medrxiv.org
Background The outbreak of coronavirus disease 2019 (COVID-19) in Wuhan City, China
has spreads rapidly since December, 2019. Most patients show mild symptoms, but some of …