A key aspect of atherosclerosis is the maladaptive inflammatory response to lipoprotein
accumulation in the artery. The failure to decrease lipid accumulation, to clear apoptotic …

Macrophage immunometabolism, the changes in intracellular metabolic pathways that alter
the function of these highly plastic cells, has been the subject of intense interest in the past …

Initiation and progression of atherosclerosis depend on local inflammation and
accumulation of lipids in the vascular wall. Although many cells are involved in the …

Macrophage accumulation within the vascular wall is a hallmark of atherosclerosis. In
atherosclerotic lesions, macrophages respond to various environmental stimuli, such as …

The role of the macrophage is of fundamental interest in understanding atherosclerotic
lesion development and thrombogenicity. After differentiation from blood peripheral …

Despite recent advances in our understanding of macrophage proliferation and apoptosis in
atherosclerotic plaques, it remains unclear whether manipulating these processes will be …

Introduction• Current concepts in monocyte heterogeneity• Pro‐atherogenic role of plaque
macrophages• Anti‐atherogenic role of plaque macrophages• Macrophage heterogeneity …

In atherosclerosis, the accumulation of apolipoprotein B-lipoproteins in the matrix beneath
the endothelial cell layer of blood vessels leads to the recruitment of monocytes, the cells of …

Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty
deposits in the inner walls of vessels. These plaques restrict blood flow and lead to …

Atherosclerosis can be regarded as a chronic inflammatory state, in which macrophages
play different and important roles. Phagocytic proinflammatory cells populate growing …