6-Bromoindirubin-3′-Oxime Suppresses LPS-Induced Inflammation via Inhibition of the TLR4/NF-κB and TLR4/MAPK Signaling Pathways

C Liu, X Tang, W Zhang, G Li, Y Chen, A Guo, C Hu - Inflammation, 2019 - Springer
We investigated the efficacy of the traditional herbal extract 6-bromoindirubin-3′-oxime
(BIO) against lipopolysaccharide (LPS)-induced mastitis in mice and inflammatory signaling …

Indirubin treatment of lipopolysaccharide‐induced mastitis in a mouse model and activity in mouse mammary epithelial cells

J Lai, Y Liu, Y Peng, P Ge, C He, C Liu… - Mediators of …, 2017 - Wiley Online Library
Indirubin is a Chinese medicine extracted from indigo and known to be effective for treating
chronic myelogenous leukemia, neoplasia, and inflammatory disease. This study evaluated …

Indirubin Inhibits LPS-Induced Inflammation via TLR4 Abrogation Mediated by the NF-kB and MAPK Signaling Pathways

J Lai, Y Liu, C Liu, M Qi, R Liu, X Zhu, Q Zhou, Y Chen… - Inflammation, 2017 - Springer
Indirubin plays an important role in the treatment of many chronic diseases and exhibits
strong anti-inflammatory activity. However, the molecular mode of action during mastitis …

Rutin protects against lipopolysaccharide-induced mastitis by inhibiting the activation of the NF-κB signaling pathway and attenuating endoplasmic reticulum stress

S Su, X Li, S Li, P Ming, Y Huang, Y Dong, H Ding… - …, 2019 - Springer
Rutin, found widely in traditional Chinese medicine materials, is used to treat eye swelling
and pain, hypertension, and hyperlipidemia. In the present study, a mouse mastitis model …

Magnolol inhibits the inflammatory response in mouse mammary epithelial cells and a mouse mastitis model

W Wei, L Dejie, S Xiaojing, W Tiancheng, C Yongguo… - Inflammation, 2015 - Springer
Mastitis comprises an inflammation of the mammary gland, which is almost always linked
with bacterial infection. The treatment of mastitis concerns antimicrobial substances, but not …

Geniposide plays an anti-inflammatory role via regulating TLR4 and downstream signaling pathways in lipopolysaccharide-induced mastitis in mice

X Song, W Zhang, T Wang, H Jiang, Z Zhang, Y Fu… - Inflammation, 2014 - Springer
Geniposide is a medicine isolated from Gardenia jasminoides Ellis, which is a traditional
Chinese herb that is widely used in Asia for the treatment of inflammation, brain diseases …

Baicalein attenuates inflammatory responses by suppressing TLR4 mediated NF-κB and MAPK signaling pathways in LPS-induced mastitis in mice

X He, Z Wei, E Zhou, L Chen, J Kou, J Wang… - International …, 2015 - Elsevier
Baicalein is a phenolic flavonoid presented in the dry roots of Scutellaria baicalensis Georgi.
It has been reported that baicalein possesses a number of biological properties, such as …

Anti‐inflammatory effects of berberine hydrochloride in an LPS‐induced murine model of mastitis

X Wang, S Feng, N Ding, Y He, C Li… - Evidence‐based …, 2018 - Wiley Online Library
Berberine hydrochloride is an isoquinoline type alkaloid extracted from Berberidaceae,
Rutaceae, and other plants. Previous reports have shown that berberine hydrochloride has …

Morin alleviates LPS-induced mastitis by inhibiting the PI3K/AKT, MAPK, NF-κB and NLRP3 signaling pathway and protecting the integrity of blood-milk barrier

A Jiang, Y Zhang, X Zhang, D Wu, Z Liu, S Li… - International …, 2020 - Elsevier
Mastitis is a common veterinary clinical disease that restricts the development of dairy
farming around the world. Morin, extracted from Mulberry Tree and other herbs, has been …

Thymol inhibits LPS-stimulated inflammatory response via down-regulation of NF-κB and MAPK signaling pathways in mouse mammary epithelial cells

D Liang, F Li, Y Fu, Y Cao, X Song, T Wang, W Wang… - Inflammation, 2014 - Springer
Thymol is a natural monoterpene phenol primarily found in thyme, oregano, and tangerine
peel. It has been shown to possess anti-inflammatory property both in vivo and in vitro. In the …