Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the viral pathogen
responsible for the current coronavirus disease 2019 (COVID-19) pandemic. As of 19 May …

We report a live-attenuated SARS-CoV-2 vaccine candidate with (i) re-engineered viral
transcription regulator sequences and (ii) deleted open-reading-frames (ORF) 3, 6, 7, and 8 …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome contains nine
open reading frames (ORFs) that encode for accessory proteins which, although …

The development of mouse models for coronavirus disease 2019 (COVID-19) has enabled
testing of vaccines and therapeutics and defining aspects of severe acute respiratory …

Background Wildtype mice are not susceptible to SARS-CoV-2 infection. Emerging SARS-
CoV-2 variants, including B. 1.1. 7, B. 1.351, P. 1, and P. 3, contain mutations in spike that …

Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
COVID-19, a disease that involves significant lung tissue damage. How SARS-CoV-2 …

SARS-CoV-2 variants have emerged with enhanced pathogenicity and transmissibility, and
escape from pre-existing immunity, suggesting first-generation vaccines and monoclonal …

The COVID-19 pandemic has resulted in upwards of 6.8 million deaths over the past three
years, and the frequent emergence of variants continues to strain global health. Although …

The recent emergence of multiple SARS‐CoV‐2 variants has caused considerable concern
due to both reduced vaccine efficacy and escape from neutralizing antibody therapeutics. It …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the current
pandemic, resulting in millions of deaths worldwide. Increasingly contagious variants of …