Uncontrolled extracellular matrix production by fibroblasts in response to tissue injury
contributes to fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF), a progressive …

Excessive extracellular matrix production by fibroblasts in response to tissue injury
contributes to fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF). Epithelial …

Loss of microRNA-29 (miR-29) is known to be a mechanism of transforming growth factor-β
(TGF-β)-mediated pulmonary fibrosis, but the therapeutic implication of miR-29 for …

Aberrant proliferation and activation of lung fibroblasts contribute to the initiation and
progression of idiopathic pulmonary fibrosis (IPF). However, the mechanisms responsible for …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and high-lethality fibrotic lung
disease characterized by excessive fibroblast proliferation, extracellular matrix …

Pulmonary fibrosis is a pathological condition in which lungs become scarred due to the
excess extracellular matrix (ECM) deposition and structural alterations in the interstitium of …

Idiopathic pulmonary fibrosis (IPF) is a fatal disorder resulting from the progressive
remodeling of lungs, with no known effective treatment. Although transforming growth factor …

MicroRNAs (miRNA) are small regulatory RNAs that control gene expression by
translational suppression and destabilization of target mRNAs. There is increasing evidence …

Transforming growth factor (TGF)-β1, a main profibrogenic cytokine in the progression of
idiopathic pulmonary fibrosis (IPF), induces differentiation of pulmonary fibroblasts to …

Although microRNAs (miRs) have been well recognized to play an important role in the
pathogenesis of organ fibrosis, there is a lack of evidence as to whether miRs directly …