Comparison of the responses of human melanocytes with different melanin contents to ultraviolet B irradiation

D Barker, K Dixon, EE Medrano, D Smalara, S Im… - Cancer Research, 1995 - AACR
Melanin is thought to serve in photoprotection. To investigate this, we have compared the
responses of cultured human melanocytes derived from different pigmentary phenotypes …

[HTML][HTML] Melanin content of cultured human melanocytes and UV-induced cytotoxicity

SM De Leeuw, NPM Smit, M Van Veldhoven… - … of Photochemistry and …, 2001 - Elsevier
Cultured melanocytes originating from persons with different skin phototypes were utilized
for measurement of endonuclease sensitive sites induced by UVB and the determination of …

Melanin: a two edged sword?

HZ Hill, W Li, P Xin, DL Mitchell - Pigment cell research, 1997 - Wiley Online Library
Melanin is both photosensitizer and photoprotector. Skin cancer rates decrease with
increasing constitutive pigmentation, yet the pigment has been shown to be photoreactive …

[HTML][HTML] The role of melanin in the induction of oxidative DNA base damage by ultraviolet A irradiation of DNA or melanoma cells

E Kvam, RM Tyrrell - Journal of Investigative Dermatology, 1999 - Elsevier
Highly pigmented, dark skin is more resistant to the harmful effects of solar ultraviolet
radiation than light-colored human skin. The extent to which tanning protects skin from …

Human skin responses to UV radiation: pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis

Y Yamaguchi, K Takahashi, BZ Zmudzka… - The FASEB …, 2006 - Wiley Online Library
Melanin plays an important role in protecting the skin against UV radiation, and melanomas
and basal/squamous cell carcinomas occur more frequently in individuals with fair/light skin …

Melanin reduces ultraviolet-induced DNA damage formation and killing rate in cultured human melanoma cells

N Kobayashi, T Muramatsu, Y Yamashina… - Journal of investigative …, 1993 - Elsevier
Epidermal melanin pigment is believed to prevent development of ultraviolet (UV)–induced
skin cancer by shielding cell nuclei and reducing DNA damage formation. It has not been …

Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiation: factors influencing the incidence of skin cancer

Y Yamaguchi, JZ Beer, VJ Hearing - Archives of Dermatological Research, 2008 - Springer
Ultraviolet (UV)-induced skin cancers, including melanomas and basal/squamous cell
carcinomas, occur more frequently in individuals with fair skin than in those with dark skin …

[HTML][HTML] Pigmented melanocytes are protected against ultraviolet-A-induced membrane damage

E Kvam, J Dahle - Journal of investigative dermatology, 2003 - Elsevier
The dominant skin pigment melanin is believed to protect human skin against several
harmful effects of ultraviolet radiation. It is not clear, however, how melanin located inside …

Analysis of the UV‐induced melanogenesis and growth arrest of human melanocytes

Z ABDEL‐MALEK, V Swope, D Smalara… - Pigment cell …, 1994 - Wiley Online Library
Cultured human melanocytes derived from different skin types responded to frequent
treatment with ultraviolet (UV) light with increased melanin synthesis, decreased …

UVA, pheomelanin and the carcinogenesis of melanoma

HZ Hill, GJ HILL - Pigment Cell Research, 2000 - Wiley Online Library
Cloudman S91 mouse melanoma cells vary in constitutive and inducible melanin levels.
Survival, mutation induction and DNA damage were quantitated after exposure to UVB, UVA …