Infection, immunoregulation, and cancer

GAW Rook, A Dalgleish - Immunological reviews, 2011 - Wiley Online Library
As man has moved rapidly from the hunter–gatherer environment to the living conditions of
the industrialized countries, the incidences of some cancers have increased alarmingly …

Infection and cancer: revaluation of the hygiene hypothesis

K Oikonomopoulou, D Brinc, K Kyriacou… - Clinical Cancer …, 2013 - AACR
Several studies have shown that persistent infections and inflammation can favor
carcinogenesis. At the same time, certain types of pathogens and antitumor immune …

Regulatory T cells: friend or foe in immunity to infection?

KHG Mills - Nature Reviews Immunology, 2004 - nature.com
Homeostasis in the immune system depends on a balance between the responses that
control infection and tumour growth and the reciprocal responses that prevent inflammation …

Humoral immunity, inflammation and cancer

TT Tan, LM Coussens - Current opinion in immunology, 2007 - Elsevier
Clinical and experimental data now clearly indicate that chronic inflammation significantly
contributes to cancer development. Emerging out of these studies is an appreciation that …

[HTML][HTML] Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies

X Liu, L Yin, S Shen, Y Hou - Genes & Diseases, 2023 - Elsevier
Chronic inflammation caused by persistent infections and metabolic disorders is thought to
contribute to the increased cancer risk and the accelerated cancer progression. Oppositely …

Perspectives on cancer immuno‐epidemiology

K Nakachi, T Hayashi, K Imai, Y Kusunoki - Cancer science, 2004 - Wiley Online Library
Estimating human cancer risk based on host‐environment interaction is one task of
epidemiology, and it has provided indispensable knowledge for prevention of cancer. The …

Cancer and inflammation: an old intuition with rapidly evolving new concepts

G Trinchieri - Annual review of immunology, 2012 - annualreviews.org
Recent scientific advances have contributed much to the dissection of the complex
molecular and cellular pathways involved in the connection between cancer and …

Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms

E Elinav, R Nowarski, CA Thaiss, B Hu, C Jin… - Nature Reviews …, 2013 - nature.com
Inflammation is a fundamental innate immune response to perturbed tissue homeostasis.
Chronic inflammatory processes affect all stages of tumour development as well as therapy …

Inflammation and cancer: advances and new agents

SM Crusz, FR Balkwill - Nature reviews Clinical oncology, 2015 - nature.com
Tumour-promoting inflammation is considered one of the enabling characteristics of cancer
development. Chronic inflammatory disease increases the risk of some cancers, and strong …

T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion?

DE Speiser, DT Utzschneider, SG Oberle… - Nature Reviews …, 2014 - nature.com
Chronic viral infections and malignant tumours induce T cells that have a reduced ability to
secrete effector cytokines and have upregulated expression of the inhibitory receptor PD1 …