Our understanding of human pre-implantation development is limited by the availability of
human embryos and cannot completely rely on mouse studies. Petropoulos et al. now …

Transcriptional and epigenetic profiling of single-cells has advanced our knowledge of the
molecular bases of gastrulation and early organogenesis. However, current approaches rely …

The preimplantation mouse embryo is a simple self-contained system, making it an excellent
model to discover how mammalian cells function in real time and in vivo. Work over the last …

Mammalian pre-implantation development is a complex process involving dramatic changes
in the transcriptional architecture,,,. We report here a comprehensive analysis of …

The placenta is one of the most important yet least understood organs. Due to the limitations
of conventional research approaches, we are still far from a comprehensive understanding …

Transcriptional regulation is pivotal to the specification of distinct cell types during embryonic
development. However, it still lacks a systematic way to identify key transcription factors …

Traditionally, the mouse has been the favoured vertebrate model for biomedical research,
due to its experimental and genetic tractability. However, non-rodent embryological studies …

Following gastrulation, the three primary germ layers develop into the major organs in a
process known as organogenesis. Single-cell RNA sequencing has enabled the profiling of …

Mammalian organogenesis is a remarkable process. Within a short timeframe, the cells of
the three germ layers transform into an embryo that includes most of the major internal and …

Spatiotemporal orchestration of gene expression is required for proper embryonic
development. The use of single-cell technologies has begun to provide improved resolution …