Lost in deletion: The enigmatic ORF8 protein of SARS-CoV-2

L Zinzula - Biochemical and biophysical research communications, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome contains nine
open reading frames (ORFs) that encode for accessory proteins which, although …

[HTML][HTML] SARS-CoV-2 ORF8 and SARS-CoV ORF8ab: genomic divergence and functional convergence

S Mohammad, A Bouchama, B Mohammad Alharbi… - Pathogens, 2020 - mdpi.com
The COVID-19 pandemic, in the first seven months, has led to more than 15 million
confirmed infected cases and 600,000 deaths. SARS-CoV-2, the causative agent for COVID …

[HTML][HTML] Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19

J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

[HTML][HTML] Variations in Orf3a protein of SARS-CoV-2 alter its structure and function

GK Azad, PK Khan - Biochemistry and biophysics reports, 2021 - Elsevier
Severe acquired respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread
worldwide and acquired multiple mutations in its genome. Orf3a, an accessory protein …

Discovery and genomic characterization of a 382-nucleotide deletion in ORF7b and ORF8 during the early evolution of SARS-CoV-2

YCF Su, DE Anderson, BE Young, M Linster, F Zhu… - MBio, 2020 - Am Soc Microbiol
To date, limited genetic changes in the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) genome have been described. Here, we report a 382-nucleotide (nt) deletion …

[HTML][HTML] SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression

A Nemudryi, A Nemudraia, T Wiegand, J Nichols… - Cell Reports, 2021 - cell.com
Summary Over 950,000 whole-genome sequences of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) have been determined for viruses isolated from around the …

[HTML][HTML] A unique view of SARS-CoV-2 through the lens of ORF8 protein

SS Hassan, AAA Aljabali, PK Panda, S Ghosh… - Computers in biology …, 2021 - Elsevier
Immune evasion is one of the unique characteristics of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) attributed to its ORF8 protein. This protein modulates the …

Evolutionary dynamics of the SARS-CoV-2 ORF8 accessory gene

F Pereira - Infection, Genetics and Evolution, 2020 - Elsevier
The new SARS-CoV-2 poses a significant threat to human health but many aspects of its
basic biology remain unknown. Its genome encodes accessory genes that differ significantly …

SARS-CoV-2 variants combining spike mutations and the absence of ORF8 may be more transmissible and require close monitoring

F Pereira - Biochemical and biophysical research communications, 2021 - Elsevier
Abstract The SARS-CoV-2 Variant of Concern 202012/01 (VOC-202012/01) emerged in
southeast England and rapidly spread worldwide. This variant is believed to be more …

ORF10–Cullin-2–ZYG11B complex is not required for SARS-CoV-2 infection

EL Mena, CJ Donahue, LP Vaites, J Li… - Proceedings of the …, 2021 - National Acad Sciences
In order to understand the transmission and virulence of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), it is necessary to understand the functions of each of the gene …