Spiky nanostructures with geometry-matching topography for virus inhibition

C Nie, M Stadtmüller, H Yang, Y Xia, T Wolff… - Nano …, 2020 - ACS Publications
Geometry-matching has been known to benefit the formation of stable biological interactions
in natural systems. Herein, we report that the spiky nanostructures with matched topography …

Heteromultivalent topology-matched nanostructures as potent and broad-spectrum influenza A virus inhibitors

C Nie, M Stadtmüller, B Parshad, M Wallert… - Science …, 2021 - science.org
Here, we report the topology-matched design of heteromultivalent nanostructures as potent
and broad-spectrum virus entry inhibitors based on the host cell membrane. Initially, we …

Piercing of the human parainfluenza virus by nanostructured surfaces

SWL Mah, DP Linklater, V Tzanov, PH Le… - ACS …, 2023 - ACS Publications
This paper presents a comprehensive experimental and theoretical investigation into the
antiviral properties of nanostructured surfaces and explains the underlying virucidal …

Topology‐matching design of an influenza‐neutralizing spiky nanoparticle‐based inhibitor with a dual mode of action

C Nie, B Parshad, S Bhatia, C Cheng… - Angewandte …, 2020 - Wiley Online Library
In this study, we demonstrate the concept of “topology‐matching design” for virus inhibitors.
With the current knowledge of influenza A virus (IAV), we designed a nanoparticle‐based …

Water-borne nanocoating for rapid inactivation of SARS-CoV-2 and other viruses

VA Bobrin, SP Chen, CF Grandes Reyes, B Sun… - ACS …, 2021 - ACS Publications
The rise in coronavirus variants has resulted in surges of the disease across the globe. The
mutations in the spike protein on the surface of the virion membrane not only allow for …

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

PA Koenig, H Das, H Liu, BM Kümmerer, FN Gohr… - Science, 2021 - science.org
INTRODUCTION The global scale and rapid spread of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) pose unprecedented challenges to society, health care …

Think like a virus: toward improving Nanovaccine Development against SARS-CoV-2

NA Mohamed, H Abou-Saleh, HA Mohamed… - Viruses, 2022 - mdpi.com
There is no doubt that infectious diseases present global impact on the economy, society,
health, mental state, and even political aspects, causing a long-lasting dent, and the …

Biomedical nanoparticle design: What we can learn from viruses

SM Figueroa, D Fleischmann, A Goepferich - Journal of Controlled Release, 2021 - Elsevier
Viruses are nanomaterials with a number of properties that surpass those of many synthetic
nanoparticles (NPs) for biomedical applications. They possess a rigorously ordered …

Nano-based approaches in the development of antiviral agents and vaccines

Y Li, Y Xiao, Y Chen, K Huang - Life sciences, 2021 - Elsevier
Outbreaks and the rapid transmission of viruses, such as coronaviruses and influenza
viruses, are serious threats to human health. A major challenge in combating infectious …

Antiviral activity of peptide-based assemblies

T Hu, O Agazani, S Nir, M Cohen, S Pan… - ACS Applied Materials …, 2021 - ACS Publications
The COVID-19 pandemic highlighted the importance of developing surfaces and coatings
with antiviral activity. Here, we present, for the first time, peptide-based assemblies that can …