Uromodulin: More than a marker for chronic kidney disease progression

K LaFavers, PS Garimella - Current Opinion in Nephrology and …, 2023 - journals.lww.com
Uromodulin: more than a marker for chronic kidney disease pr... : Current Opinion in Nephrology
and Hypertension Uromodulin: more than a marker for chronic kidney disease progression …

The versatile role of uromodulin in renal homeostasis and its relevance in chronic kidney disease

T Takata, H Isomoto - Internal Medicine, 2024 - jstage.jst.go.jp
Uromodulin, also known as the Tamm-Horsfall protein, is predominantly expressed in
epithelial cells of the kidney. It is secreted mainly in the urine, although small amounts are …

Uromodulin identified as a potential therapeutic target

R Kirk - Nature Reviews Nephrology, 2014 - nature.com
Novel findings have shown a link between the genetic susceptibility to salt-sensitive
hypertension and chronic kidney disease (CKD) and the level of uromodulin expression …

Uromodulin in kidney health and disease

PS Garimella, MJ Sarnak - Current opinion in nephrology and …, 2017 - journals.lww.com
Over the last decade, we have begun to understand the functional role of uromodulin in
health and disease. Large prospective studies in generalizable populations are needed to …

Uromodulin: roles in health and disease

C Schaeffer, O Devuyst… - Annual review of …, 2021 - annualreviews.org
Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

Uromodulin biology

AG Karagiannidis… - Nephrology Dialysis …, 2024 - academic.oup.com
Uromodulin is a kidney-specific glycoprotein which is exclusively produced by the epithelial
cells lining the thick ascending limb and early distal convoluted tubule. It is currently …

Evolving concepts in uromodulin biology, physiology, and its role in disease: a tale of two forms

KA LaFavers, R Micanovic, AR Sabo, LA Maghak… - …, 2022 - Am Heart Assoc
Uromodulin (or Tamm-Horsfall protein) is a glycoprotein uniquely produced in the kidney by
tubular cells of the thick ascending limb of the loop of Henle and early distal tubules. This …

Evidence for a role of uromodulin in chronic kidney disease progression

S Prajczer, U Heidenreich, W Pfaller… - Nephrology Dialysis …, 2010 - academic.oup.com
Background. Uromodulin (also known as Tamm–Horsfall protein) is the most abundant
urinary protein in healthy individuals and exhibits diverse functions including prevention of …

Uromodulin as a potential candidate marker for predicting the course of chronic kidney disease

LD Denova - KIDNEYS, 2021 - kidneys.zaslavsky.com.ua
Uromodulin is a nephrospecific protein that is most common in normal urine. And although it
has been known for more than 70 years, the function of uromodulin remains unclear …

Uromodulin-can it be a new marker of kidney damage?

A Fugiel, M Kuzniewski, D Fedak - Przeglad lekarski, 2013 - europepmc.org
Uromodulin (Tamm-Horsfall protein) is the most abundant protein excreted in the urine
under physiological conditions. It is exclusively produced in the kidney and secreted into the …