Several interventions, such as ischemic preconditioning, remote pre/perconditioning, or
postconditioning, are known to decrease lethal myocardial ischemia-reperfusion injury …

Vascular pathologies pose a significant health problem because of their wide prevalence
and high impact on the rate of mortality. Blockade of blood flow in major blood vessels leads …

Several signal transduction pathways are activated by cardioprotective stimuli, including
ischemic or pharmacological postconditioning. These pathways converge on a common …

Mitochondria are increasingly recognized as lynchpins in the evolution of cardiac injury
during ischemia and reperfusion. This review addresses the emerging concept that …

Mitochondrial damage is a determining factor in causing loss of cardiomyocyte function and
viability, yet a mild degree of mitochondrial dysfunction appears to underlie cardioprotection …

BACKGROUND: There is increasing evidence documenting the capacity of myocardial cells
exposed to a variety of insults to mount a cardioprotective response. Although this …

The resurgence of mitochondrial biology research stems from the realization that the distinct
regulation of mitochondria to meet diverse homeostatic demands is driven by exquisite …

The ischemic heart requires reperfusion using clinical interventions, such as coronary artery
bypass graft surgery, in order to recover. Despite recent developments in myocardial …

Mitochondria play a central role in the protection conferred by ischemic preconditioning (IP)
by not fully elucidated mechanisms. We investigated whether IP protects mitochondria …

Reperfusion therapy must be applied as soon as possible to attenuate the ischemic insult of
acute myocardial infarction (AMI). However reperfusion is responsible for additional …