While recent experiments revealed that some pioneer transcription factors (TFs) can bind to
their target DNA sequences inside a nucleosome, the binding dynamics of their target …

Transcription factor (TF) proteins bind to DNA to regulate gene expression. Normally,
accessibility to DNA is required for their function. However, in the nucleus, the DNA is often …

All major biological processes start after protein molecules known as transcription factors
detect specific regulatory sequences on DNA and initiate genetic expression by associating …

Cooperativity in transcription factor (TF) binding is essential in eukaryotic gene regulation
and arises through diverse mechanisms. Here, we focus on one mechanism, collaborative …

Pioneer transcription factors are proteins that induce cellular identity transitions by binding to
inaccessible regions of DNA in nuclear chromatin. They contribute to chromatin opening and …

Nucleosomes drastically limit transcription factor (TF) occupancy, while pioneer transcription
factors (PFs) somehow circumvent this nucleosome barrier. In this study, we compare …

Transcription factors (TF) require access to target sites within nucleosomes to initiate
transcription. The target site position within the nucleosome significantly influences TF …

Genome wide maps of nucleosome occupancy in yeast have recently been produced
through deep sequencing of nuclease-protected DNA. These maps have been obtained …

Critical lineage commitment events are staged by multiple transcription factors (TFs) binding
to their cognate motifs, often positioned at nucleosome-enriched regions of chromatin. The …

Binding of transcription factors (TFs) to regulatory sequences is a pivotal step in the control
of gene expression. Despite many advances in the characterization of sequence motifs …