Cellular Uptake of the ATSM− Cu (II) Complex under Hypoxic Conditions
GR Walke, S Meron, Y Shenberger… - …, 2021 - Wiley Online Library
Abstract The Cu (II)‐diacetyl‐bis (N4‐methylthiosemicarbazone) complex (ATSM− Cu (II))
has been suggested as a promising positron emission tomography (PET) agent for hypoxia …
has been suggested as a promising positron emission tomography (PET) agent for hypoxia …
Cu–ATSM: A radiopharmaceutical for the PET imaging of hypoxia
AL Vāvere, JS Lewis - Dalton transactions, 2007 - pubs.rsc.org
Copper (II)-diacetyl-bis (N4-methylthiosemicarbazone), Cu–ATSM, labeled with a positron
emitting isotope of copper (60Cu, 61Cu, 62Cu or 64Cu) has been shown, in vitro and in vivo …
emitting isotope of copper (60Cu, 61Cu, 62Cu or 64Cu) has been shown, in vitro and in vivo …
Investigation into 64Cu-labeled Bis (selenosemicarbazone) and Bis (thiosemicarbazone) complexes as hypoxia imaging agents
P McQuade, KE Martin, TC Castle, MJ Went… - Nuclear medicine and …, 2005 - Elsevier
BACKGROUND: Cu-diacetyl-bis (N4-methylthiosemicarbazone)[Cu-ATSM], although
excellent for oncology applications, may not be suitable for delineating cardiovascular or …
excellent for oncology applications, may not be suitable for delineating cardiovascular or …
[PDF][PDF] Preliminary imaging studies of [61Cu] diacetyl-bis (N4-methylthiosemi-carbazone) in normal and hypoxic tumor models
AR Jalilian, H Yousefnia, DM KAMALI, S Moradkhani… - 2010 - sid.ir
Introduction:[61 Cu] diacetyl-bis (N 4-methylthiosemicarbazone)([61 Cu] ATSM) is a well-
established hypoxia imaging tracer with simple production and significant specifity. In this …
established hypoxia imaging tracer with simple production and significant specifity. In this …
[HTML][HTML] Assessing tumor hypoxia by positron emission tomography with Cu-ATSM
For the last several decades, hypoxia has been recognized to be one of the key factors in
tumor aggression and an important impediment to local and distant control of malignant …
tumor aggression and an important impediment to local and distant control of malignant …
A dual radiolabelling approach for tracking metal complexes: investigating the speciation of copper bis(thiosemicarbazonates) in vitro and in vivo
R Hueting, V Kersemans, M Tredwell… - Metallomics, 2015 - academic.oup.com
Abstract Copper (ii) bis (thiosemicarbazonato) complexes such as [64Cu] Cu-ATSM
continue to be investigated for positron emission tomography (PET) imaging of tumour …
continue to be investigated for positron emission tomography (PET) imaging of tumour …
Hypoxia imaging and theranostic potential of [64Cu][Cu(ATSM)] and ionic Cu(II) salts: a review of current evidence and discussion of the retention mechanisms
T Liu, M Karlsen, AM Karlberg, KR Redalen - EJNMMI research, 2020 - Springer
Background Tumor hypoxia (low tissue oxygenation) is an adverse condition of the solid
tumor environment, associated with malignant progression, radiotherapy resistance, and …
tumor environment, associated with malignant progression, radiotherapy resistance, and …
[PDF][PDF] Preclinical studies of [Cu] ATSM as a PET radiopharmaceutical for fibrosarcoma imaging
ATSM) was prepared using in house-made diacetyl-bis (N4--methylthiosemicarbazone)(
ATSM) ligand and [61Cu] CuCl2 produced via the natZn (p, x) 61Cu (180 mA proton …
ATSM) ligand and [61Cu] CuCl2 produced via the natZn (p, x) 61Cu (180 mA proton …
PET imaging of hypoxia with [64] Cu-ATSM in human ovarian cancer: Comparison of xenografts in mice and rats
JT Joergensen, J Madsen, A Kjaer - Cancer Research, 2011 - AACR
Abstract Aim:[64] Cu-ATSM (Cu-ATSM) is a promising hypoxia tracer for PET imaging.
However, relatively low uptake is seen in human xenografts in mice compared to patients …
However, relatively low uptake is seen in human xenografts in mice compared to patients …
64Cu-ATSM/64Cu-Cl2 and their relationship to hypoxia in glioblastoma: a preclinical study
EA Pérès, J Toutain, LP Paty, D Divoux, M Ibazizène… - EJNMMI research, 2019 - Springer
Abstract Background Diacetyl-bis (N4-methylthiosemicarbazone), labeled with 64Cu (64 Cu-
ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various …
ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various …