Being different multifactorial forms of psychopathology, aggression, depression and suicidal
behavior, which is considered to be violent aggression directed against the self, have …

Among an impressive variety of identified serotonin receptors, 5-HT 1A attracts particular
attention due to its central role in the regulation of 5-HT-ergic neurotransmission and the …

The serotonergic (5-HT) system has been widely implicated in the pathophysiology of Major
Depressive Disorder (MDD). Although the 5-HT system is a popular target for drug therapy in …

Alterations in serotonin (5-HT) neurochemistry have been implicated in the aetiology of all
major neuropsychiatric disorders, ranging from schizophrenia to mood and anxiety-spectrum …

Mental disorders, such as depression and anxiety, pose both medical and social challenges.
The clinical efficacy of current antidepressant/anxiolytic therapies is unsatisfactory; both …

BACKGROUND: Several lines of evidence suggest a clear relationship between serotonin
(5-hydroxytryptamine, 5-HT) hypoactivity and suicidal behavior across several psychiatric …

The therapeutic effects induced by serotonin-selective reuptake inhibitor (SSRI)
antidepressants are initially triggered by blocking the serotonin transporter and rely on long …

Abstract Serotonin 2A (5-HT 2A) and 5-HT 2C receptors are highly homologous members of
the serotonin 2 family of 7-transmembrane-spanning (7-TMS) receptors. Both of these …

The serotonin 4 receptor, 5-HT4R, represents one of seven different serotonin receptor
families and is implicated in a variety of physiological functions and their pathophysiological …

Azapirones, selective partial agonists at the 5-HT 1A receptor subtype, induce hypothermia
and corticotropin (ACTH)/cortisol release as specific functional correlates of central 5-HT 1A …