Abstract Rationale Serotonin reuptake inhibitors (SSRIs) are effective in treating depression.
Given the existence of different families and subtypes of 5-HT receptors, multiple 5-HT …

5-HT1B receptors are expressed throughout the mammalian central nervous system. These
receptors are located in the axon terminals of both serotonergic and nonserotonergic …

To examine further the hypothesis that the magnitude of the intrinsic activity of agonists at 5-
HT1A receptors determines the magnitude of their psychotropic activity, we studied the …

Evidence from the various sources indicates alterations in 5-HT 2C receptor functions in
anxiety, depression and suicide, and other stress-related disorders treated with …

Several lines of evidence support a role for serotoninergic (5-HT) system abnormalities in
the pathogenesis and treatment of several psychiatric disorders. This review summarizes …

Aggressive individuals have higher rates of mental illness compared to non-aggressive
individuals. Multiple factors, including psychosocial, genetic, and neurobiological …

The introduction of buspirone for the treatment of anxiety, together with the eventual
suggestion of a mode of action involving the serotonin (5-HT) 1A receptor subtype, has …

Serotonin is a widely investigated neurotransmitter in several psychopathologies, including
suicidal behavior (SB); however, its role extends to several physiological functions involving …

Rationale The 5-HT 7 receptor is a more recently discovered G-protein-coupled receptor for
serotonin. The functions and possible clinical relevance of this receptor are not yet fully …

Major depression and anxiety are highly prevalent and involve chronic dysregulation of
serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic …