We studied the prevalent cytotoxic CD8 T cell response mounted against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein 269-277 epitope …

The emergence of SARS-CoV-2 variants of concern (VOC) is driven by mutations that
mediate escape from neutralizing antibodies. There is also evidence that mutations can …

SARS-CoV-2 variants that escape neutralization and potentially affect vaccine efficacy have
emerged. T cell responses play a role in protection from reinfection and severe disease, but …

There is a growing concern that ongoing evolution of SARS-CoV-2 could lead to variants of
concern (VOC) that are capable of avoiding some or all of the multifaceted immune …

T cells play a vital role in combatting SARS-CoV-2 and forming long-term memory
responses. Whereas extensive structural information is available on neutralizing antibodies …

SARS-CoV-2 can mutate to evade immunity, with consequences for the efficacy of emerging
vaccines and antibody therapeutics. Herein we demonstrate that the immunodominant …

COVID-19 pandemic remains an on-going global health and economic threat that has
amassed millions of deaths. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

An improved understanding of human T cell-mediated immunity in COVID-19 is important for
optimizing therapeutic and vaccine strategies. Experience with influenza shows that …

CD4+ T cells recognize a broad range of peptide epitopes of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), which contribute to immune memory and limit …

Unrelated individuals can produce genetically similar clones of antibodies, known as public
clonotypes, which have been seen in responses to different infectious diseases, as well as …