Blood vessels in the mammalian skeletal system control bone formation and support
haematopoiesis by generating local niche environments. While a specialized capillary …

Tissue engineering provides unique opportunities for regenerating diseased or damaged
tissues using cells obtained from tissue biopsies. Tissue engineered grafts can also be used …

Recently, blood vessels have been implicated in the morphogenesis of various organs. The
vasculature is also known to be essential for endochondral bone development, yet the …

In addition to their conventional role as a versatile transport system, blood vessels provide
signals controlling organ development, regeneration, and stem cell behavior. In the skeletal …

Adequate vascularization is an absolute requirement for bone development, growth,
homeostasis, and repair. Endochondral ossification during fetal skeletogenesis is typified by …

Inadequate vascularization of engineered tissue constructs is a main challenge in
developing a clinically impactful therapy for large, complex, and recalcitrant bone defects. It …

The replacement of cartilage by bone is the net result of genetic programs that control
chondrocyte differentiation, matrix degradation, and bone formation. Disruptions in the rate …

During the initiation of endochondral ossification three events occur that are inextricably
linked in time and space: chondrocytes undergo terminal differentiation and cell death, the …

Bone marrow endothelial cells (BMECs) play a key role in bone formation and
haematopoiesis. Although recent studies uncovered the cellular taxonomy of stromal …

Growth plate cartilage contributes to the generation of a large variety of shapes and sizes of
skeletal elements in the mammalian system. The removal of cartilage and how this process …