Sepsis is a devastating and complex syndrome and continues to be a major cause of
morbidity and mortality among critically ill patients at the surgical intensive care unit setting …

Review on sepsis mediators, and roles in innate and adaptive immune systems, as well as
implications for therapeutics. Sepsis refers to severe systemic inflammation in response to …

Sepsis is a very heterogeneous clinical syndrome broadly defined as the systemic host
response to an infection. Until recently, the concept that mortality is the consequence of an …

Sepsis is the systematic response to infection. In septic patients who develop severe
disease, excessive inflammation damages the lungs, liver, kidneys, and cardiovascular …

Sepsis and septic shock are among the leading causes of death in intensive care units
worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the …

Sepsis is defined as “a life‐threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection.” At present, sepsis continues to …

Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Sepsis syndrome and septic shock remain significant causes of morbidity and mortality. To
date, clinical trials of novel agents to treat sepsis have failed to demonstrate clinical efficacy …

Sepsis is one of the most common reasons for critically ill patients to be admitted to an
intensive care unit and, despite advances in overall medical care, it represents a major …

Therapy for severe sepsis and septic shock remains a major unmet medical need and novel
treatments to regulate the disordered inflammatory response in sepsis are needed if …