The glycosylation in SARS-CoV-2 and its receptor ACE2

Y Gong, S Qin, L Dai, Z Tian - Signal Transduction and Targeted …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), a highly infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than …

Glycosylation of SARS-CoV-2: structural and functional insights

A Shajahan, LE Pepi, DS Rouhani, C Heiss… - Analytical and …, 2021 - Springer
The COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2). Similar to other coronaviruses, its particles are composed of four structural …

Comprehensive characterization of N-and O-glycosylation of SARS-CoV-2 human receptor angiotensin converting enzyme 2

A Shajahan, S Archer-Hartmann, NT Supekar… - …, 2021 - academic.oup.com
The emergence of the coronavirus disease 2019 (COVID-19) pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created the need for …

Glycosylation is a key in SARS-CoV-2 infection

CA Reis, R Tauber, V Blanchard - Journal of Molecular Medicine, 2021 - Springer
SARS-CoV-2 causes the respiratory syndrome COVID-19 and is responsible for the current
pandemic. The S protein of SARS-CoV-2-mediating virus binding to target cells and …

[HTML][HTML] Subtle influence of ACE2 glycan processing on SARS-CoV-2 recognition

JD Allen, Y Watanabe, H Chawla, ML Newby… - Journal of molecular …, 2021 - Elsevier
The severity of SARS-CoV-2 infection is highly variable and yet the molecular basis for this
effect remains elusive. One potential contribution are differences in the glycosylation of …

The role of the SARS-CoV-2 S-protein glycosylation in the interaction of SARS-CoV-2/ACE2 and immunological responses

E Ramirez Hernandez, LF Hernandez-Zimbron… - Viral …, 2021 - liebertpub.com
The current pandemic is caused by the coronavirus disease 2019 (COVID-19), which is, in
turn, induced by a novel coronavirus (SARS-CoV-2) that triggers an acute respiratory …

Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro

HC Huang, YJ Lai, CC Liao, FY Wang, KB Huang… - …, 2021 - thelancet.com
Background Despite clinical success with anti-spike vaccines, the effectiveness of
neutralizing antibodies and vaccines has been compromised by rapidly spreading SARS …

Inhibition of Protein N-Glycosylation Blocks SARS-CoV-2 Infection

A Casas-Sanchez, A Romero-Ramirez, E Hargreaves… - MBio, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) extensively N-glycosylates
its spike proteins, which are necessary for host cell invasion and the target of both vaccines …

Protein post-translational modification in SARS-CoV-2 and host interaction

N Cheng, M Liu, W Li, BY Sun, D Liu, G Wang… - Frontiers in …, 2023 - frontiersin.org
SARS-CoV-2 can cause lung diseases, such as pneumonia and acute respiratory distress
syndrome, and multi-system dysfunction. Post-translational modifications (PTMs) related to …

[HTML][HTML] Mass spectrometry analysis of newly emerging coronavirus HCoV-19 spike protein and human ACE2 reveals camouflaging glycans and unique post …

Z Sun, K Ren, X Zhang, J Chen, Z Jiang, J Jiang, F Ji… - Engineering, 2021 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic has led to worldwide efforts to
understand the biological traits of the newly identified human coronavirus (HCoV-19) virus …