Chronic inflammatory arthritis, a hallmark of several inflammatory rheumatic diseases, and
inflammatory bowel disease are both life-long conditions, with substantial morbidity and …

Ankylosing spondylitis (AS) is a common inflammatory arthritic condition. Overt inflammatory
bowel disease (IBD) occurs in about 10% of AS patients, and in addition 70% of AS cases …

Modern technological innovations have advanced our understanding of the genetic basis of
spondyloarthritis. In ankylosing spondylitis (AS), where the major histocompatibility complex …

Objective Patients with ankylosing spondylitis (AS) and∼ 50% of their first‐degree relatives
may have a genetic abnormality that results in subclinical intestinal inflammation. This study …

Background Genome-wide association studies have identified a plethora of risk genes for
both Crohn's disease (CD) and ankylosing spondylitis (AS). A subset of genes found to be …

Background A multicenter genome-wide association scan for Crohn's Disease (CD) has
recently reported 40 CD susceptibility loci, including 29 novel ones (19 significant and 10 …

The close association between inflammatory bowel disease (IBD) and inflammatory arthritis,
including ankylosing spondylitis (AS), is well recognized; however, new interest has been …

Ankylosing spondylitis (AS) is the prototypic form of axial spondyloarthritis (axSpA). It is
highly heritable, with studies conducted in twins and in unrelated cases and controls …

Ankylosing spondylitis (AS), psoriasis and inflammatory bowel disease (IBD) often coexist in
the same patient and in their families. In AS, genes within the MHC region, in particular HLA …

The findings suggest that further genome-wide studies in large case–control cohorts are
likely to be very productive in this disease. The IL23R findings and subsequent …