The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE)
lineages coincident with implantation of the embryo. The epiblast subsequently undergoes …

Mouse embryonic development is a canonical model system for studying mammalian cell
fate acquisition. Recently, single-cell atlases comprehensively charted embryonic …

Gastrulation of the mouse embryo entails progressive restriction of lineage potency and the
organization of the lineage progenitors into a body plan. Here we performed a high …

Understanding of the molecular drivers of lineage diversification and tissue patterning
during primary germ layer development requires in-depth knowledge of the dynamic …

It is now recognized that extensive expression heterogeneities among cells precede the
emergence of lineages in the early mammalian embryo. To establish a map of pluripotent …

During post-implantation development of the mouse embryo, descendants of the inner cell
mass in the early epiblast transit from the naive to primed pluripotent state. Concurrently …

Mammalian embryogenesis is characterized by rapid cellular proliferation and
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …

Following implantation, the epiblast (EPI) cells transit from the naive to primed pluripotency,
accompanied by dynamic changes in X chromosome activity in females. To investigate the …

Intercellular communication is essential to coordinate the behaviour of individual cells
during organismal development. The preimplantation mammalian embryo is a paradigm of …

The preimplantation period of mouse early embryonic development is devoted to the
specification of two extraembryonic tissues and their spatial segregation from the pluripotent …