Testing whether the mean vector of a multivariate set of biomarkers differs between several
populations is an increasingly common problem in medical research. Biomarker data is …

There has been an explosive growth in the development of statistical methodology over the
past several decades. Research in both medicine and public health, in which the …

A biological medicine (or biologicals) is a term for a medicinal compound that is derived from
a living organism. By their very nature, they are complex and often heterogeneous in …

This paper presents an extension to the recently published OnPLS data analysis method. Bi‐
modal OnPLS allows for arbitrary block relationships in both columns and rows and is able …

In modern medical research, it is rare to limit data analysis to merely two variables: a single
exposure (independent) variable and a single outcome (dependent) variable. Most …

Background While several algorithms for the comparison of univariate distributions arising
from flow cytometric analyses have been developed and studied for many years, algorithms …

This article considers receiver operating characteristic (ROC) analysis for bivariate marker
measurements. The research interest is to extend tools and rules from univariate marker to …

In observational studies, the first step is usually to explore data distribution and the baseline
differences between groups. Data description includes their central tendency (eg, mean …