SARS-CoV-2 spike protein: flexibility as a new target for fighting infection

CL Pierri - Signal Transduction and Targeted Therapy, 2020 - nature.com
The spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
crucial for the infection because it mediates the virus entry into human host-cells, through …

Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2

A Singh, G Steinkellner, K Köchl, K Gruber… - Scientific reports, 2021 - nature.com
Since the worldwide outbreak of the infectious disease COVID-19, several studies have
been published to understand the structural mechanism of the novel coronavirus SARS-CoV …

The SARS-CoV-2 spike protein: balancing stability and infectivity

I Berger, C Schaffitzel - Cell research, 2020 - nature.com
SARS-CoV-2 spike (S) glycoprotein is the key target of current vaccine development efforts
to combat COVID-19; neutralizing antibodies bind S and interfere with S binding to its …

An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

Y Liu, WT Soh, J Kishikawa, M Hirose, EE Nakayama… - Cell, 2021 - cell.com
Antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein
prevent SARS-CoV-2 infection. However, the effects of antibodies against other spike …

Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development

SK Samrat, AM Tharappel, Z Li, H Li - Virus research, 2020 - Elsevier
The recent outbreak of the betacoronavirus SARS-CoV-2 has become a significant concern
to public health care worldwide. As of August 19, 2020, more than 22,140,472 people are …

[HTML][HTML] A cryptic site of vulnerability on the receptor binding domain of the SARS-CoV-2 spike glycoprotein

MG Joyce, RS Sankhala, WH Chen, M Choe, H Bai… - BioRxiv, 2020 - ncbi.nlm.nih.gov
SUMMARY SARS-CoV-2 is a zoonotic virus that has caused a pandemic of severe
respiratory disease—COVID-19—within several months of its initial identification …

Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

C Yi, X Sun, J Ye, L Ding, M Liu, Z Yang, X Lu… - Cellular & molecular …, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus
SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein …

A potent neutralizing human antibody reveals the N-terminal domain of the Spike protein of SARS-CoV-2 as a site of vulnerability

X Chi, R Yan, J Zhang, G Zhang, Y Zhang, M Hao… - BioRxiv, 2020 - biorxiv.org
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) presents a global public health threat. Most …

The SARS-CoV-2 spike glycoprotein as a drug and vaccine target: structural insights into its complexes with ACE2 and antibodies

AC Papageorgiou, I Mohsin - Cells, 2020 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of
the Coronavirus disease (COVID-19) pandemic, has so far resulted in more than 1.1 M …

Structural basis of a human neutralizing antibody specific to the SARS-CoV-2 spike protein receptor-binding domain

M Yang, J Li, Z Huang, H Li, Y Wang, X Wang… - Microbiology …, 2021 - Am Soc Microbiol
The emerging new lineages of severe acute respiratory syndrome coronavirus-2 (SARS-
CoV-2) have marked a new phase of coronavirus disease 2019 (COVID-19). Understanding …