Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation
K Obata, H Yamanaka, K Kobayashi, Y Dai… - Journal of …, 2004 - Soc Neuroscience
To investigate whether activation of mitogen-activated protein kinase (MAPK) in damaged
and/or undamaged primary afferents participates in neuropathic pain after partial nerve …
and/or undamaged primary afferents participates in neuropathic pain after partial nerve …
Differential activation of MAPK in injured and uninjured DRG neurons following chronic constriction injury of the sciatic nerve in rats
K Obata, H Yamanaka, Y Dai… - European Journal of …, 2004 - Wiley Online Library
To investigate the intracellular signal transduction pathways involved in the
pathophysiological mechanisms of neuropathic pain after partial nerve injury, we examined …
pathophysiological mechanisms of neuropathic pain after partial nerve injury, we examined …
Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity
Bradykinin potentiates synaptic glutamate release and action in the spinal cord via
presynaptic and postsynaptic B2 receptors, contributing thereby to activity-dependent central …
presynaptic and postsynaptic B2 receptors, contributing thereby to activity-dependent central …
Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in …
W Ma, R Quirion - Pain, 2002 - Elsevier
The activation of glial cells in the spinal dorsal horn and the gracile nucleus by inflammation
and nerve injury has been suggested to be involved in neuronal plasticity and central …
and nerve injury has been suggested to be involved in neuronal plasticity and central …
Activation of p38 MAP kinase is involved in central neuropathic pain following spinal cord injury
Recent work regarding chronic central neuropathic pain (CNP) following spinal cord injury
(SCI) suggests that activation of key signaling molecules such as members of the mitogen …
(SCI) suggests that activation of key signaling molecules such as members of the mitogen …
Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury
R Terayama, S Omura, N Fujisawa, T Yamaai… - Neuroscience, 2008 - Elsevier
The activation of glial cells in the CNS has been suggested to be involved in abnormal pain
sensation after peripheral nerve injury. Previous studies demonstrated phosphorylation of …
sensation after peripheral nerve injury. Previous studies demonstrated phosphorylation of …
The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain …
Peripheral inflammation induces persistent central sensitization characterized by
mechanical allodynia and heat hyperalgesia that are mediated by distinct mechanisms …
mechanical allodynia and heat hyperalgesia that are mediated by distinct mechanisms …
Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury
H Katsura, K Obata, T Mizushima, J Sakurai… - Journal of …, 2006 - Soc Neuroscience
Hypersensitivity to mechanical stimulation is a well documented symptom of neuropathic
pain, for which there is currently no effective therapy. Src-family kinases (SFKs) are involved …
pain, for which there is currently no effective therapy. Src-family kinases (SFKs) are involved …
Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following inflammation near the nerve cell body
K Obata, H Yamanaka, Y Dai, T Mizushima, T Fukuoka… - Neuroscience, 2004 - Elsevier
Inflammation of the primary afferent proximal to the dorsal root ganglion (DRG) and the DRG
itself is known to produce radicular pain. Here, we examined pain-related behaviors and the …
itself is known to produce radicular pain. Here, we examined pain-related behaviors and the …
Tumor necrosis factor-α induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons
M Schäfers, CI Svensson, C Sommer… - Journal of …, 2003 - Soc Neuroscience
Tumor necrosis factor-α (TNF) is implicated in the initiation of neuropathic pain. In vitro, TNF
activates p38 mitogen-activated kinase. Accordingly, we investigated whether TNF activates …
activates p38 mitogen-activated kinase. Accordingly, we investigated whether TNF activates …
相关搜索
- mechanical allodynia nerve ligation
- nerve injury mechanical hypersensitivity
- nerve injury protein kinase
- spinal microglia mechanical hypersensitivity
- activation of microglia protein kinase
- drg neurons differential activation
- root ganglion protein kinase
- horn neurons pain hypersensitivity
- p38 mapk nerve ligation
- drg neurons sciatic nerve
- differential activation sciatic nerve
- nerve injury spinal microglia
- tactile allodynia protein kinase
- src family mechanical hypersensitivity
- column nucleus protein kinase
- nerve injury activation of microglia