[HTML][HTML] Reducing mortality and morbidity in patients with severe COVID-19 disease by advancing ongoing trials of Mesenchymal Stromal (stem) Cell (MSC) therapy …

A Zumla, FS Wang, G Ippolito, N Petrosillo… - International Journal of …, 2020 - Elsevier
As of May 17th 2020, the novel coronavirus disease 2019 (COVID-19) pandemic has
caused 307,395 deaths worldwide, out of 3,917,366 cases reported to the World Health …

The use of mesenchymal stromal cells in the treatment of coronavirus disease 2019

MA Canham, JDM Campbell, JC Mountford - Journal of Translational …, 2020 - Springer
More than seven months into the coronavirus disease-19 (COVID-19) pandemic, infection
from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to over …

Efficacy of MSC in patients with severe COVID-19: analysis of the literature and a case study

M Grumet, J Sherman, BS Dorf - Stem cells translational …, 2022 - academic.oup.com
Patients with severe COVID-19 experience cytokine storm, an uncontrolled upregulation of
pro-inflammatory cytokines, which if unresolved leads to acute respiratory distress syndrome …

Mesenchymal stromal cells in viral infections: implications for COVID-19

JLM Rocha, WCF de Oliveira, NC Noronha… - Stem cell reviews and …, 2021 - Springer
Mesenchymal stromal cells (MSCs) constitute a heterogeneous population of stromal cells
with immunomodulatory and regenerative properties that support their therapeutic use …

Clinical efficacy and mechanism of mesenchymal stromal cells in treatment of COVID-19

K Lu, S Geng, S Tang, H Yang, W Xiong, F Xu… - Stem cell research & …, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a highly infectious epidemic disease that
has seriously affected human health worldwide. To date, however, there is still no definitive …

Mesenchymal stem/stromal cell therapy for COVID-19 pneumonia: potential mechanisms, current clinical evidence, and future perspectives

W Yao, L Shi, Y Zhang, H Dong, Y Zhang - Stem Cell Research & Therapy, 2022 - Springer
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread into more than 200 countries …

Updated living systematic review and meta-analysis of controlled trials of mesenchymal stromal cells to treat COVID-19: a Framework for Accelerated Synthesis of Trial …

AM Kirkham, AJM Bailey, M Monaghan… - Stem cells …, 2022 - academic.oup.com
Abstract Background Mesenchymal stromal cells (MSCs) may reduce mortality in patients
with COVID-19; however, early evidence is based on few studies with marked interstudy …

Safety and efficacy of mesenchymal stem cells in severe/critical patients with COVID-19: A systematic review and meta-analysis

W Yao, H Dong, J Qi, Y Zhang, L Shi - EClinicalMedicine, 2022 - thelancet.com
Background The present study aims to better understand the efficacy and safety of
mesenchymal stromal cells (MSCs) in treating severe/critical patients with COVID-19 …

Mesenchymal stem/stromal cell–based therapies for COVID-19: First iteration of a living systematic review and meta-analysis: MSCs and COVID-19

AM Kirkham, M Monaghan, AJM Bailey, R Shorr… - Cytotherapy, 2022 - Elsevier
Background Mesenchymal stem/stromal cells (MSCs) and their secreted products are a
promising therapy for COVID-19 given their immunomodulatory and tissue repair …

Current status of cell-based therapies for COVID-19: evidence from mesenchymal stromal cells in sepsis and ARDS

Z Xu, Y Huang, J Zhou, X Deng, W He, X Liu… - Frontiers in …, 2021 - frontiersin.org
The severe respiratory consequences of the coronavirus disease 2019 (COVID-19)
pandemic have prompted the urgent need for novel therapies. Cell-based therapies …