Genome-wide association studies in nephrology research
A Köttgen - American Journal of Kidney Diseases, 2010 - Elsevier
Kidney diseases constitute a serious public health burden worldwide, with substantial
associated morbidity and mortality. The role of a genetic contribution to kidney disease is …
associated morbidity and mortality. The role of a genetic contribution to kidney disease is …
Transcriptome-and proteome-wide association studies nominate determinants of kidney function and damage
Background The pathophysiological causes of kidney disease are not fully understood. Here
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
DI Chasman, C Fuchsberger, C Pattaro… - Human molecular …, 2012 - academic.oup.com
In conducting genome-wide association studies (GWAS), analytical approaches leveraging
biological information may further understanding of the pathophysiology of clinical traits. To …
biological information may further understanding of the pathophysiology of clinical traits. To …
[HTML][HTML] A systems view of genetics in chronic kidney disease
BJ Keller, S Martini, JR Sedor, M Kretzler - Kidney international, 2012 - Elsevier
A tight interplay of genetic predisposition and environmental factors define the onset and the
rate of progression of chronic renal disease. We are seeing a rapid expansion of information …
rate of progression of chronic renal disease. We are seeing a rapid expansion of information …
The genetics of common kidney disease: a pathway toward clinical relevance
PE Drawz, JR Sedor - Nature Reviews Nephrology, 2011 - nature.com
Genome-wide association studies (GWASs) have advanced our understanding of the
genetic basis for common renal diseases, including chronic kidney disease (CKD) and …
genetic basis for common renal diseases, including chronic kidney disease (CKD) and …
Chronic kidney disease: novel insights from genome-wide association studies
CA Böger, IM Heid - Kidney and Blood Pressure Research, 2011 - karger.com
Chronic kidney disease (CKD) is common, affecting about 10% of the general population,
and causing significant morbidity and mortality. Apart from the risk conferred by traditional …
and causing significant morbidity and mortality. Apart from the risk conferred by traditional …
Genome-wide analysis studies and chronic kidney disease
In recent years, the very high worldwide prevalence of chronic kidney disease (CKD) has led
some authors to talk of an “epidemic.” The progression of CKD varies considerably among …
some authors to talk of an “epidemic.” The progression of CKD varies considerably among …
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies
AP Morris, TH Le, H Wu, A Akbarov… - Nature …, 2019 - nature.com
Chronic kidney disease (CKD) affects~ 10% of the global population, with considerable
ethnic differences in prevalence and aetiology. We assemble genome-wide association …
ethnic differences in prevalence and aetiology. We assemble genome-wide association …
A clustering approach to improve our understanding of the genetic and phenotypic complexity of chronic kidney disease
Chronic kidney disease (CKD) is a complex disorder that causes a gradual loss of kidney
function, affecting approximately 9.1% of the world's population. Here, we use a soft …
function, affecting approximately 9.1% of the world's population. Here, we use a soft …
Molecular insights into genome-wide association studies of chronic kidney disease-defining traits
Genome-wide association studies (GWAS) have identified> 100 loci of chronic kidney
disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations …
disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations …